Battistelli S, Marcheggiani F, Stella F, Pecorella I, Troccoli R
Istituto di Istologia ed Analisi di Laboratorio, Università di Urbino.
Boll Soc Ital Biol Sper. 1990 Oct;66(10):985-92.
The evaluation of CEA serum levels and CEA tissue staining is one of the most common parameters used to help in the diagnosis and prognosis of colon-rectum disease. To this aim, an immunohistochemical demonstration of the CEA was carried out with the ABC staining system in sections of normal and diseased colon. 24 patients with polyps of the large intestine, 17 with rectocolitis, 22 with colon-rectum cancer and 11 normal subjects were studied. Results were positive in 9, 1% of the normal mucosa, 37, 5% of the polyps, 41, 2% of the rectocolitis and 100% of the carcinomas. However, the CEA in the positive reactions showed different degrees of staining and different cellular localization. From our results it would appear that the intracellular localization of this marker is connected with the degree of atypia in the histological sections. Immunohistochemical localization of the CEA could therefore be useful, above all in assessing the prognosis of colon-rectum disease.
癌胚抗原（CEA）血清水平及CEA组织染色评估是用于辅助结直肠疾病诊断和预后判断的最常用参数之一。为此，采用ABC染色系统对正常及病变结肠切片进行CEA免疫组化检测。研究了24例大肠息肉患者、17例直肠结肠炎患者、22例结直肠癌患者及11例正常受试者。结果显示，正常黏膜中阳性率为9.1%，息肉中为37.5%，直肠结肠炎中为41.2%，癌组织中为100%。然而，阳性反应中的CEA呈现出不同程度的染色及不同的细胞定位。从我们的结果来看，该标志物的细胞内定位与组织学切片中的异型程度相关。因此，CEA的免疫组化定位可能有用，尤其在评估结直肠疾病的预后方面。
