Gebauer G, Müller-Ruchholtz W
Department of Gynecology and Obstetrics, University Erlangen-Nuremberg, Germany.
Anticancer Res. 1997 Jul-Aug;17(4B):2939-42.
Tumor markers CEA, CA19-9, CA15-3, CA125, AFP, beta-HCG, SCC were measured quantitatively in the serum, tumor tissue and healthy colonic mucosa of patients with colorectal cancer. We wanted to investigated whether there is a difference in concentration between patients with and without recurrence of cancer. During the follow-up period 14 of 38 patients showed tumor recurrence. The patients with cancer relapse had higher preoperative serum levels of CEA and CA19-9 and in the histologically normal colonic mucosa they had higher concentrations of CEA, CA19-9, SCC and low CA15-3. The highest values of CEA, CA19-9, and SCC occurred in the mucosa of patients developing local cancer recurrence. Marker concentrations in tumor tissues themselves did not differ between patients with or without tumor relapse. Though confirmation in a larger number of cases is needed we conclude from these results that tumor marker concentrations in the healthy colonic mucosa of patients with colorectal cancer may become valuable indicators of the risk of tumor recurrence.
对结直肠癌患者的血清、肿瘤组织及健康结肠黏膜进行了癌胚抗原（CEA）、糖类抗原19-9（CA19-9）、糖类抗原15-3（CA15-3）、糖类抗原125（CA125）、甲胎蛋白（AFP）、β-人绒毛膜促性腺激素（β-HCG）、鳞状细胞癌抗原（SCC）的定量检测。我们想要研究癌症复发患者与未复发患者的标志物浓度是否存在差异。在随访期间，38例患者中有14例出现肿瘤复发。癌症复发患者术前血清CEA和CA19-9水平较高，在组织学正常的结肠黏膜中，他们的CEA、CA19-9、SCC浓度较高，而CA15-3浓度较低。CEA、CA19-9和SCC的最高值出现在发生局部癌症复发患者的黏膜中。肿瘤组织本身的标志物浓度在有或无肿瘤复发的患者之间没有差异。尽管需要更多病例进行证实，但从这些结果我们得出结论，结直肠癌患者健康结肠黏膜中的肿瘤标志物浓度可能成为肿瘤复发风险的有价值指标。
