Janknegt R, Paulissen A, Hooymans P M, Lohman J J, Hermens W A
Department of Clinical Pharmacy, Maasland Hospital, Sittard, The Netherlands.
Perit Dial Int. 1990;10(4):287-9.
Amphotericin B is the drug of choice in continuous ambulatory peritoneal dialysis (CAPD) associated fungal peritonitis and is usually administered intraperitoneally. The drug is stated to be incompatible with anions. All CAPD fluids contain chloride and lactate anions. Therefore, the physical and chemical compatibility of amphotericin B with dextrose 5%, Dianeal 1.36% CAPD fluid, and Dianeal 1.36% peritoneal effluent was studied at amphotericin B concentrations of 1, 2, and 5 mg/L. Amphotericin B was most stable in Dianeal CAPD fluid. The rate of degradation was concentration dependent in dextrose 5% and peritoneal effluent. The higher the concentration, the lower the rate of degradation. After an incubation of 6 h at 37 degrees C, no significant decomposition was found at all concentrations studied in Dianeal CAPD fluid whereas 12-18% decomposition was found in effluent. No physical incompatibility with any solution was observed.
两性霉素B是持续性非卧床腹膜透析（CAPD）相关真菌性腹膜炎的首选药物，通常通过腹腔内给药。据称该药物与阴离子不相容。所有CAPD液都含有氯离子和乳酸根阴离子。因此，研究了两性霉素B在浓度为1、2和5mg/L时与5%葡萄糖、1.36%的Dianeal CAPD液以及1.36%的Dianeal腹膜流出液的物理和化学相容性。两性霉素B在Dianeal CAPD液中最稳定。在5%葡萄糖和腹膜流出液中，降解速率与浓度有关。浓度越高，降解速率越低。在37℃孵育6小时后，在所有研究浓度的Dianeal CAPD液中均未发现明显分解，而在流出液中发现12 - 18%的分解。未观察到与任何溶液存在物理不相容性。
