低强度激光疗法预防骨髓移植患者口腔黏膜炎的随机临床试验。
The prevention of induced oral mucositis with low-level laser therapy in bone marrow transplantation patients: a randomized clinical trial.
作者信息
Silva Geisa Badauy Lauria, Mendonça Elismauro Francisco, Bariani Cesar, Antunes Heliton Spindola, Silva Maria Alves Garcia
机构信息
Hematopoietic Stem Cell Transplant Unit, Araújo Jorge Hospital, Goiás Fight Cancer Association, Goiânia, Goiás, Brazil.
出版信息
Photomed Laser Surg. 2011 Jan;29(1):27-31. doi: 10.1089/pho.2009.2699. Epub 2010 Oct 22.
BACKGROUND DATA AND OBJECTIVE
Patients who have received high doses of chemotherapy, either alone or in combination with total body irradiation often cite oral mucositis (OM) as the most debilitating side effect. The aim of this study was to investigate the clinical effects of low-level laser therapy (LLLT) on the prevention of conditioning-induced OM in hematopoietic stem cell transplantation (HSCT).
METHODS
We randomized 42 patients who underwent autologous or allogeneic HSCT. A low-level InGaAlP diode laser was used, emitting light at 660 nm, 40 mW, and 4 J/cm(2). An evaluation of OM was carried out using the World Health Organization scale.
RESULTS AND CONCLUSION
In the LLLT group, 57.1% of patients had an OM grade 0, 9.6% had grade 1, and 33.3% had grade 2, whereas in the control group, only 4.8% of patients were free of OM (grade 0). Our results indicate that the preventive use of LLLT in patients who have undergone HSCT is a powerful instrument in reducing OM incidence.
背景数据与目的
接受高剂量化疗（单独使用或联合全身照射）的患者常称口腔黏膜炎（OM）是最具致残性的副作用。本研究旨在探讨低强度激光疗法（LLLT）对预防造血干细胞移植（HSCT）中预处理诱导的OM的临床效果。
方法
我们将42例行自体或异基因HSCT的患者随机分组。使用一台低强度铟镓铝磷二极管激光器，发射波长660nm、功率40mW、能量密度4J/cm²的光。采用世界卫生组织量表对OM进行评估。
结果与结论
在LLLT组中，57.1%的患者OM为0级，9.6%为1级，33.3%为2级；而在对照组中，仅有4.8%的患者无OM（0级）。我们的结果表明，在接受HSCT的患者中预防性使用LLLT是降低OM发生率的有力手段。
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