Pillai Jisha K, Mysore Venkataram
Department of Dermocosmetology, Lilavati Hospital and Research Centre, Bandra, Mumbai, India.
J Cutan Aesthet Surg. 2021 Oct-Dec;14(4):385-391. doi: 10.4103/JCAS.JCAS_218_20.
Androgenetic alopecia (AGA) is the commonest type of alopecia affecting over half of men and women. Only two drugs have been approved so far (minoxidil and finasteride), and hair transplant is the other treatment alternative. Low-level laser therapy (LLLT) has been claimed to be a new safe devise-based modality for stimulating hair growth in men and women in AGA. Searches of PubMed and Google Scholar were carried out using keywords alopecia, hair loss, and LLLT. Fifteen studies were found to be strongly relevant and were analyzed. Studies have shown that LLLT stimulated hair growth in both men and women. Studies with largest randomized controlled trials demonstrated statistically significant hair regrowth by terminal hair count in both males and females. One study also showed that LLLT and minoxidil had similar efficacy in hair growth and that combination therapy was even more effective. LLLT represents a non-invasive, safe, and potentially effective treatment option for patients with AGA who do not respond or are not tolerant to standard treatment of AGA. Moreover, combining LLLT with topical minoxidil solution and oral finasteride may act synergistic to enhance hair regrowth. However, the level of evidence of the studies is still low and hence more controlled large studies are needed.
雄激素性脱发（AGA）是最常见的脱发类型，影响超过一半的男性和女性。到目前为止，只有两种药物被批准（米诺地尔和非那雄胺），植发是另一种治疗选择。低能量激光疗法（LLLT）据称是一种基于设备的新型安全方法，可刺激AGA患者（无论男女）头发生长。使用关键词“脱发”“掉发”和“LLLT”在PubMed和谷歌学术上进行了检索。发现15项研究高度相关并进行了分析。研究表明，LLLT可刺激男性和女性头发生长。最大规模的随机对照试验研究表明，通过终毛计数，男性和女性的毛发再生在统计学上具有显著意义。一项研究还表明，LLLT和米诺地尔在促进头发生长方面具有相似的疗效，联合治疗甚至更有效。对于对AGA标准治疗无反应或不耐受的AGA患者，LLLT是一种非侵入性、安全且可能有效的治疗选择。此外，将LLLT与外用米诺地尔溶液和口服非那雄胺联合使用可能具有协同作用，以促进毛发再生。然而，这些研究的证据水平仍然较低，因此需要更多的对照大型研究。
