帕金森病患者苍白球刺激与丘脑底核刺激后的药物剂量减少。

Medication dose reductions after pallidal versus subthalamic stimulation in patients with Parkinson's disease.

机构信息

Department of Neurology Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.

出版信息

Acta Neurol Scand. 2011 Sep;124(3):211-4. doi: 10.1111/j.1600-0404.2010.01455.x. Epub 2010 Oct 25.

DOI:10.1111/j.1600-0404.2010.01455.x

PMID:20969559

Abstract

OBJECTIVE

To compare the medication dose reduction between deep brain stimulation (DBS) of the globus pallidus interna (GPi) vs subthalamic nucleus (STN) in matched patients with Parkinson's disease (PD).

MATERIALS AND METHODS

Records of 12 patients with PD who underwent GPi-DBS at our institution from 2002 to 2008 were matched by pre-operative PD medication doses and pre-operative motor Unified Parkinson's Disease Rating Scale (UPDRS) scores to 12 cases of STN-DBS. PD medication doses were converted to levodopa equivalent doses (LEDs).

RESULTS

GPi and STN groups had similar mean pre-operative LEDs and motor UPDRS scores. At 6 months post-DBS, there was no significant difference in percent reduction in LEDs between the GPi (47.95%) and STN (37.47%) groups (P = 0.52). The mean post-operative 'medication off/stimulation on' motor UPDRS scores did not differ significantly between GPi (15.33) and STN (16.25) groups (P = 0.74). The mean percent reduction in motor UPDRS scores was also similar between GPi (58.44%) and STN (58.98%) patients (P = 0.94).

CONCLUSIONS

We conclude that in disease-matched patients with PD undergoing DBS, both GPi and STN may result in similar reduction in PD medication doses.

摘要

目的

比较内侧苍白球（GPi）与丘脑底核（STN）深部脑刺激（DBS）在帕金森病（PD）患者中的药物剂量减少情况。

材料与方法

本研究回顾性分析了 2002 年至 2008 年在我院行 GPi-DBS 的 12 例 PD 患者的病历资料，通过术前 PD 药物剂量和术前运动性统一帕金森病评定量表（UPDRS）评分与 12 例 STN-DBS 患者进行匹配。将 PD 药物剂量转换为左旋多巴等效剂量（LEDs）。

结果

GPi 组和 STN 组患者的术前平均 LEDs 和运动性 UPDRS 评分相似。DBS 术后 6 个月，GPi 组（47.95%）和 STN 组（37.47%）之间 LEDs 减少百分比无显著差异（P = 0.52）。GPi 组（15.33）和 STN 组（16.25）术后“关药/开刺激”运动性 UPDRS 评分无显著差异（P = 0.74）。GPi 组（58.44%）和 STN 组（58.98%）患者的运动性 UPDRS 评分减少百分比也相似（P = 0.94）。