多能造血祖细胞中的淋巴样和髓样谱系定向。
Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors.
机构信息
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Immunol Rev. 2010 Nov;238(1):37-46. doi: 10.1111/j.1600-065X.2010.00963.x.
Abstract
Hematopoietic stem cells (HSCs) continuously replenish all classes of blood cells through a series of lineage restriction steps that results in the progressive loss of differentiation potential to other cell lineages. This review focuses on the recent advances in understanding one of the earliest differentiation steps in HSC maturation, which involves the diversification of the lymphoid and myeloid cell lineages, the two major branches of hematopoietic cells. We discuss progress in the identification and characterization of progenitor populations downstream of HSCs, which has been a key to understanding the sequential biological events that take place along the course of differentiation into a certain hematopoietic cell type. We also discuss the importance of bone marrow microenvironment in lymphoid and myeloid lineage choice.
摘要
造血干细胞（HSCs）通过一系列谱系限制步骤不断补充所有类别的血细胞，这些步骤导致向其他细胞谱系分化的潜力逐渐丧失。本综述重点介绍了对 HSC 成熟过程中最早的分化步骤之一的理解的最新进展，该步骤涉及淋巴细胞和髓系细胞谱系的多样化，这是造血细胞的两个主要分支。我们讨论了鉴定和表征 HSCs 下游祖细胞群体的进展，这是理解沿着特定造血细胞类型分化过程中发生的连续生物学事件的关键。我们还讨论了骨髓微环境在淋巴细胞和髓系谱系选择中的重要性。
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