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本文引用的文献

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Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance.缺乏证据表明造血干细胞依赖N-钙黏蛋白介导的与成骨细胞的黏附来维持其功能。
Cell Stem Cell. 2007 Aug 16;1(2):204-17. doi: 10.1016/j.stem.2007.06.001.
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Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.原癌基因LRF对B淋巴细胞与T淋巴细胞谱系命运决定的调控
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Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.胎儿和成体干细胞以及多能祖细胞中分级转录谱系启动的分子证据。
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Identification of a bone marrow precursor of the earliest thymocytes in adult mouse.成年小鼠中最早胸腺细胞的骨髓前体细胞的鉴定。
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Selective thymus settling regulated by cytokine and chemokine receptors.由细胞因子和趋化因子受体调控的选择性胸腺定植。
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Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.骨髓基质细胞龛中CXCL12-CXCR4趋化因子信号传导对造血干细胞池的维持作用。
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Immune reconstitution after purified autologous and allogeneic blood stem cell transplantation compared with unmanipulated bone marrow transplantation in children.儿童纯化自体和异体血干细胞移植后与未处理骨髓移植相比的免疫重建
Br J Haematol. 2006 Oct;135(1):76-84. doi: 10.1111/j.1365-2141.2006.06244.x. Epub 2006 Aug 22.
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Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potential.骨髓中具有T系重建潜能的原始淋巴祖细胞。
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Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors.多能造血祖细胞中不对称的淋巴细胞和髓细胞系定向分化
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10
New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors.支持flk2/flt3+多能造血祖细胞具有巨核细胞-红细胞分化潜能的新证据。
Cell. 2006 Jul 28;126(2):415-26. doi: 10.1016/j.cell.2006.06.037.

T淋巴细胞和B淋巴细胞从造血干细胞的分化过程。

T and B lymphocyte differentiation from hematopoietic stem cell.

作者信息

Lai Anne Y, Kondo Motonari

机构信息

Department of Immunology, Duke University Medical Center, 101 Jones Building, DUMC Box 3010, Research Drive, Durham, NC 27710, United States.

出版信息

Semin Immunol. 2008 Aug;20(4):207-12. doi: 10.1016/j.smim.2008.05.002. Epub 2008 Jun 25.

DOI:10.1016/j.smim.2008.05.002
PMID:18583148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2570370/
Abstract

Until the past few years, it has been thought that lymphoid and myeloid lineage segregation represents the first step of lineage restriction during hematopoiesis from hematopoietic stem cell. Recent investigation of the cell populations within multipotent progenitors in the bone marrow has led to new understanding of how hematopoietic stem cells diversify into different hematopoietic cell types. This review focuses on the recent advances in understanding the developmental events that occur during hematopoietic stem cell specification into the T and B lymphocyte lineages in adult mice.

摘要

直到过去几年，人们一直认为淋巴系和髓系谱系分离是造血干细胞造血过程中谱系限制的第一步。最近对骨髓中多能祖细胞内细胞群体的研究，使人们对造血干细胞如何分化为不同造血细胞类型有了新的认识。这篇综述重点关注了在成年小鼠中造血干细胞分化为T和B淋巴细胞谱系过程中发生的发育事件的最新进展。