T淋巴细胞和B淋巴细胞从造血干细胞的分化过程。
T and B lymphocyte differentiation from hematopoietic stem cell.
作者信息
Lai Anne Y, Kondo Motonari
机构信息
Department of Immunology, Duke University Medical Center, 101 Jones Building, DUMC Box 3010, Research Drive, Durham, NC 27710, United States.
出版信息
Semin Immunol. 2008 Aug;20(4):207-12. doi: 10.1016/j.smim.2008.05.002. Epub 2008 Jun 25.
Abstract
Until the past few years, it has been thought that lymphoid and myeloid lineage segregation represents the first step of lineage restriction during hematopoiesis from hematopoietic stem cell. Recent investigation of the cell populations within multipotent progenitors in the bone marrow has led to new understanding of how hematopoietic stem cells diversify into different hematopoietic cell types. This review focuses on the recent advances in understanding the developmental events that occur during hematopoietic stem cell specification into the T and B lymphocyte lineages in adult mice.
摘要
直到过去几年，人们一直认为淋巴系和髓系谱系分离是造血干细胞造血过程中谱系限制的第一步。最近对骨髓中多能祖细胞内细胞群体的研究，使人们对造血干细胞如何分化为不同造血细胞类型有了新的认识。这篇综述重点关注了在成年小鼠中造血干细胞分化为T和B淋巴细胞谱系过程中发生的发育事件的最新进展。
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