ThPOK 在胸腺发育中的作用不断扩大。
Expanding roles for ThPOK in thymic development.
机构信息
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
出版信息
Immunol Rev. 2010 Nov;238(1):182-94. doi: 10.1111/j.1600-065X.2010.00958.x.
Abstract
The role of the zinc finger transcription factor ThPOK (T-helper-inducing POZ-Kruppel-like factor) in promoting commitment of αβ T cells to the CD4 lineage is now well established. New results indicate that ThPOK is also important for the development and/or acquisition of effector functions by other T cell subsets, including several not marked by CD4 expression, i.e. double-negative invariant natural killer T (iNKT) cells, γδ cells, and even memory CD8(+) T cells. There is compelling evidence that ThPOK expression in most or all of these cases is dependent on T-cell receptor signaling and that differences in relative TCR signal strength/length may induce different levels of ThPOK expression. The developmental consequences of ThPOK expression vary according to cell type, which may partly reflect differences in ThPOK levels and/or in transcriptional networks between cell types.
摘要
锌指转录因子 ThPOK（辅助性 T 细胞诱导 POZ-Krüppel 样因子）在促进 αβ T 细胞向 CD4 谱系的定向分化中起着重要作用，这一点现在已经得到了充分证实。新的研究结果表明，ThPOK 对于其他 T 细胞亚群（包括一些不表达 CD4 的亚群，如双阴性不变自然杀伤 T 细胞（iNKT）细胞、γδ 细胞，甚至是记忆性 CD8(+)T 细胞）的发育和/或效应功能的获得也很重要。有确凿的证据表明，在大多数或所有这些情况下，ThPOK 的表达都依赖于 T 细胞受体信号，而相对 TCR 信号强度/长度的差异可能诱导不同水平的 ThPOK 表达。ThPOK 表达的发育后果因细胞类型而异，这可能部分反映了细胞类型之间 ThPOK 水平和/或转录网络的差异。
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