Aithal K S, Aroor A R, Pathak Y V, Uchil J
Kasturba Medical College, Manipal.
Indian J Dent Res. 1990 Apr-Sep;2(2-3):174-81.
The formulation for the controlled release of NaF from matrix tablets using Methyl cellulose to prepare chewable NaF tablets for the prevention of dental caries is developed. Various micromeritic studies of granules and tablets containing different concentrations of matrix were studied. Dissolution studies were also carried out in distilled water at 37 +/- 1 degrees C. Significant variations in granule and tablet characteristics were observed depending upon the concentration of the Methyl cellulose used observed. The in vitro drug release reveals that, T 80% values for 30% concentration of matrix is greatest, which seems to be ideal concentration. The drug dissolution is diffusion controlled and follows the Higuchi equation. The fraction of the drug release is proportional to time 1/2 Clinical study is in progress and is encouraging.
开发了一种使用甲基纤维素从基质片剂中控制释放氟化钠的配方，以制备用于预防龋齿的可咀嚼氟化钠片剂。对含有不同浓度基质的颗粒和片剂进行了各种微观特性研究。还在37±1℃的蒸馏水中进行了溶出度研究。观察到颗粒和片剂特性存在显著差异，这取决于所使用的甲基纤维素的浓度。体外药物释放表明，30%浓度基质的T80%值最大，这似乎是理想浓度。药物溶解受扩散控制，符合 Higuchi 方程。药物释放分数与时间的1/2成正比。临床研究正在进行中，结果令人鼓舞。
