Aithal K S, Udupa D N, Tandon S
College of Pharmaceutical Sciences, Manipal Academy of Higher Education, India.
Indian J Dent Res. 1996 Oct-Dec;7(4):136-9.
Chewable tablets containing low dosage fluoride content were prepared using two varieties of celluloses and their in vitro parameters were evaluated. An eighteen month clinical trial revealed that both these formulations were effective in controlling the caries. However, ethyl cellulose is proved to be superior to methylcellulose as a controlled release matrix material in controlling caries. Thus this study recommends ethylcellulose matrix tablets containing low fluoride content is an efficacious and cost effective drug device in controlling dental caries.
使用两种纤维素制备了低剂量含氟咀嚼片，并对其体外参数进行了评估。一项为期18个月的临床试验表明，这两种制剂在控制龋齿方面均有效。然而，在控制龋齿方面，乙基纤维素被证明作为控释基质材料优于甲基纤维素。因此，本研究推荐低氟含量的乙基纤维素基质片是一种控制龋齿的有效且经济高效的药物装置。
