以癌胚抗原（CEA）初始升高为表现的甲状腺髓样癌。
Medullary thyroid carcinoma presenting with an initial CEA elevation.
作者信息
Abraham Deepak, Delbridge Leigh, Clifton-Bligh Roderick, Clifton-Bligh Phillip, Grodski Simon, Robinson Bruce G, Messina Marinella, Sidhu Stan
机构信息
University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St. Leonard's 2065 NSW, Australia.
出版信息
ANZ J Surg. 2010 Nov;80(11):831-3. doi: 10.1111/j.1445-2197.2010.05350.x.
BACKGROUND
Carcinoembryonic antigen (CEA) is a tumour marker commonly associated with gastrointestinal malignancy. Patients presenting with an elevated CEA will therefore often undergo extensive investigations in order to elucidate an underlying gastrointestinal malignancy that may not be clinically apparent. However the GI tract is not the only source of CEA elevation.
METHODS
We present a series of patients presenting with raised CEA levels that were initially investigated for a gastrointestinal cause, but after work up were detected to have medullary thyroid cancer.
RESULTS
Four patients with raised CEA were evaluated for a gastrointestinal cause for the elevation. We discuss the non gastrointestinal causes for an elevated CEA.
CONCLUSION
The paper highlights that in patients presenting with an elevated CEA, in whom a gastrointestinal cause has been ruled out, a tumour of neuroendocrine origin needs to be considered as a cause for the elevated CEA.
背景
癌胚抗原（CEA）是一种通常与胃肠道恶性肿瘤相关的肿瘤标志物。因此，癌胚抗原水平升高的患者常常会接受广泛的检查，以查明可能在临床上并不明显的潜在胃肠道恶性肿瘤。然而，胃肠道并非导致癌胚抗原升高的唯一原因。
方法
我们报告了一系列癌胚抗原水平升高的患者，这些患者最初因胃肠道病因接受检查，但检查后被诊断为甲状腺髓样癌。
结果
对4例癌胚抗原升高的患者进行了胃肠道病因评估。我们讨论了癌胚抗原升高的非胃肠道病因。
结论
本文强调，对于癌胚抗原升高且已排除胃肠道病因的患者，需考虑神经内分泌起源的肿瘤作为癌胚抗原升高的原因。
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