抑制 CD44 的 N- 和 O-糖基化可降低子宫内膜细胞系与腹膜间皮细胞的黏附。
Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells.
机构信息
Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, Texas 78229, USA.
出版信息
Fertil Steril. 2011 Feb;95(2):823-5. doi: 10.1016/j.fertnstert.2010.09.005.
Abstract
The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viability of EECs and ESCs, and the expression of CD44 surface density were evaluated. Inhibition of CD44 N- and O-linked glycosylation by using tunicamycin and/or B-GalNAc statistically significantly inhibited endometrial cell attachment to peritoneal mesothelial cells, suggesting a role in establishment of early endometriotic lesions.
摘要
评估了子宫内膜上皮细胞（EECs）和子宫内膜基质细胞（ESCs）与腹膜间皮细胞（PMCs）的附着情况，有无 N-和 O-连接糖基化的抑制作用，EECs 和 ESCs 的活力，以及 CD44 表面密度的表达情况。使用衣霉素和/或 B-GalNAc 抑制 CD44 的 N-和 O-连接糖基化，统计学上显著抑制了子宫内膜细胞与腹膜间皮细胞的附着，表明其在早期子宫内膜异位症病变的建立中起作用。
相似文献
1
Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells.抑制 CD44 的 N- 和 O-糖基化可降低子宫内膜细胞系与腹膜间皮细胞的黏附。
Fertil Steril. 2011 Feb;95(2):823-5. doi: 10.1016/j.fertnstert.2010.09.005.
2
Menstrual endometrial cells from women with endometriosis demonstrate increased adherence to peritoneal cells and increased expression of CD44 splice variants.子宫内膜异位症患者的月经子宫内膜细胞表现出对腹膜细胞的黏附增加和 CD44 剪接变异体表达增加。
Fertil Steril. 2010 Apr;93(6):1745-9. doi: 10.1016/j.fertnstert.2008.12.012. Epub 2009 Feb 6.
3
Inhibition of Hyaluronic Acid Synthesis Decreases Endometrial Cell Attachment, Migration, and Invasion.抑制透明质酸合成可降低子宫内膜细胞的黏附、迁移和侵袭能力。
Reprod Sci. 2020 Apr;27(4):1058-1063. doi: 10.1007/s43032-019-00100-w. Epub 2020 Feb 3.
4
Expression of cadherins and CD44 isoforms in human endometrium and peritoneal endometriosis.钙黏蛋白和CD44亚型在人子宫内膜及腹膜子宫内膜异位症中的表达
Acta Obstet Gynecol Scand. 2002 Mar;81(3):195-203. doi: 10.1034/j.1600-0412.2002.810302.x.
5
Activin A increases invasiveness of endometrial cells in an in vitro model of human peritoneum.激活素A在人腹膜体外模型中增加子宫内膜细胞的侵袭性。
Mol Hum Reprod. 2008 May;14(5):301-7. doi: 10.1093/molehr/gan016. Epub 2008 Mar 21.
6
Mesothelial cell-associated hyaluronic acid promotes adhesion of endometrial cells to mesothelium.间皮细胞相关的透明质酸促进子宫内膜细胞与间皮的黏附。
Fertil Steril. 2001 Nov;76(5):1012-8. doi: 10.1016/s0015-0282(01)02839-4.
7
Impaired Development of Early Endometriotic Lesions in CD44 Knockout Mice.CD44基因敲除小鼠早期子宫内膜异位症病变发育受损。
Reprod Sci. 2016 Jan;23(1):87-91. doi: 10.1177/1933719115594022. Epub 2015 Jul 12.
8
Possible involvement of CD10 in the development of endometriosis due to its inhibitory effects on CD44-dependent cell adhesion.由于 CD10 对 CD44 依赖性细胞黏附的抑制作用，其可能参与了子宫内膜异位症的发生。
Reprod Sci. 2014 Jan;21(1):82-8. doi: 10.1177/1933719113488449. Epub 2013 May 7.
9
Pathogenesis of endometriosis--current research.子宫内膜异位症的发病机制——当前研究
Hum Fertil (Camb). 2003 Feb;6(1):34-40. doi: 10.1080/1464770312331368973.
10
A novel in vitro model of the early endometriotic lesion demonstrates that attachment of endometrial cells to mesothelial cells is dependent on the source of endometrial cells.一种新型的早期子宫内膜异位症病变体外模型表明，子宫内膜细胞与间皮细胞的附着取决于子宫内膜细胞的来源。
Fertil Steril. 2005 Jul;84(1):16-21. doi: 10.1016/j.fertnstert.2004.10.058.
引用本文的文献
1
The Sweet Relationship between the Endometrium and Protein Glycosylation.子宫内膜与蛋白质糖基化的甜蜜关系。
Biomolecules. 2024 Jun 27;14(7):770. doi: 10.3390/biom14070770.
2
Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions.内源性透明质酸及其对调控腹膜粘连形成的潜在作用。
Biomolecules. 2021 Dec 29;12(1):45. doi: 10.3390/biom12010045.
3
The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights.子宫内膜异位症的发病机制：分子和细胞生物学的新见解。
Int J Mol Sci. 2019 Nov 10;20(22):5615. doi: 10.3390/ijms20225615.
4
Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis.子宫内膜细胞 α2-6 唾液酸化增加有助于子宫内膜异位症的发展。
Exp Mol Med. 2018 Dec 12;50(12):1-12. doi: 10.1038/s12276-018-0167-1.
5
Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis.癌症干细胞的糖基化：在干性、肿瘤发生和转移中的功能。
Neoplasia. 2018 Aug;20(8):813-825. doi: 10.1016/j.neo.2018.06.001. Epub 2018 Jul 6.
6
The Hyaluronic Acid System is Intact in Menstrual Endometrial Cells in Women With and Without Endometriosis.在患有和不患有子宫内膜异位症的女性的月经子宫内膜细胞中，透明质酸系统是完整的。
Reprod Sci. 2019 Jan;26(1):109-113. doi: 10.1177/1933719118766257. Epub 2018 Apr 5.
7
Excess reactive oxygen species production mediates monoclonal antibody-induced human embryonic stem cell death via oncosis.过量活性氧生成通过胀亡介导单克隆抗体诱导的人胚胎干细胞死亡。
Cell Death Differ. 2017 Mar;24(3):546-558. doi: 10.1038/cdd.2016.164. Epub 2017 Jan 20.
8
CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches.CD44 整合了正常干细胞、癌症干细胞和（前）转移龛中的信号。
Exp Biol Med (Maywood). 2013 Mar;238(3):324-38. doi: 10.1177/1535370213480714.
本文引用的文献
1
Menstrual endometrial cells from women with endometriosis demonstrate increased adherence to peritoneal cells and increased expression of CD44 splice variants.子宫内膜异位症患者的月经子宫内膜细胞表现出对腹膜细胞的黏附增加和 CD44 剪接变异体表达增加。
Fertil Steril. 2010 Apr;93(6):1745-9. doi: 10.1016/j.fertnstert.2008.12.012. Epub 2009 Feb 6.
2
Activin A increases invasiveness of endometrial cells in an in vitro model of human peritoneum.激活素A在人腹膜体外模型中增加子宫内膜细胞的侵袭性。
Mol Hum Reprod. 2008 May;14(5):301-7. doi: 10.1093/molehr/gan016. Epub 2008 Mar 21.
3
Modeling the early endometriotic lesion: mesothelium-endometrial cell co-culture increases endometrial invasion and alters mesothelial and endometrial gene transcription.早期子宫内膜异位症病变建模：间皮细胞与子宫内膜细胞共培养可增加子宫内膜侵袭并改变间皮细胞和子宫内膜的基因转录。
Fertil Steril. 2008 Oct;90(4 Suppl):1487-95. doi: 10.1016/j.fertnstert.2007.09.047. Epub 2007 Dec 27.
4
A novel in vitro model of the early endometriotic lesion demonstrates that attachment of endometrial cells to mesothelial cells is dependent on the source of endometrial cells.一种新型的早期子宫内膜异位症病变体外模型表明，子宫内膜细胞与间皮细胞的附着取决于子宫内膜细胞的来源。
Fertil Steril. 2005 Jul;84(1):16-21. doi: 10.1016/j.fertnstert.2004.10.058.
5
A novel immortalized human endometrial stromal cell line with normal progestational response.一种具有正常孕激素反应的新型永生化人子宫内膜基质细胞系。
Endocrinology. 2004 May;145(5):2291-6. doi: 10.1210/en.2003-1606. Epub 2004 Jan 15.
6
Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells.过氧化物酶体增殖物激活受体γ对人子宫内膜细胞中细胞因子的调节作用
Fertil Steril. 2003 Mar;79 Suppl 1:763-9. doi: 10.1016/s0015-0282(02)04835-5.
7
Induction of monocyte chemotactic protein-1 in peritoneal mesothelial and endometrial cells by oxidized low-density lipoprotein and peritoneal fluid from women with endometriosis.氧化型低密度脂蛋白和子宫内膜异位症患者的腹腔液诱导腹膜间皮细胞和子宫内膜细胞产生单核细胞趋化蛋白-1
Fertil Steril. 2002 Oct;78(4):843-8. doi: 10.1016/s0015-0282(02)03333-2.
8
An in vitro model to study the pathogenesis of the early endometriosis lesion.一种用于研究早期子宫内膜异位症病变发病机制的体外模型。
Ann N Y Acad Sci. 2002 Mar;955:296-307; discussion 340-2, 396-406. doi: 10.1111/j.1749-6632.2002.tb02790.x.
9
Mesothelial cell-associated hyaluronic acid promotes adhesion of endometrial cells to mesothelium.间皮细胞相关的透明质酸促进子宫内膜细胞与间皮的黏附。
Fertil Steril. 2001 Nov;76(5):1012-8. doi: 10.1016/s0015-0282(01)02839-4.
10
CD44s expression is reduced in endometriotic lesions compared to eutopic endometrium in women with endometriosis.与子宫内膜异位症患者的在位内膜相比，子宫内膜异位症病灶中CD44s的表达降低。
Int J Gynecol Pathol. 2001 Apr;20(2):140-6. doi: 10.1097/00004347-200104000-00005.
Zotero 插件