Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, Texas 78229, USA.
Fertil Steril. 2011 Feb;95(2):823-5. doi: 10.1016/j.fertnstert.2010.09.005.
The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viability of EECs and ESCs, and the expression of CD44 surface density were evaluated. Inhibition of CD44 N- and O-linked glycosylation by using tunicamycin and/or B-GalNAc statistically significantly inhibited endometrial cell attachment to peritoneal mesothelial cells, suggesting a role in establishment of early endometriotic lesions.
评估了子宫内膜上皮细胞（EECs）和子宫内膜基质细胞（ESCs）与腹膜间皮细胞（PMCs）的附着情况，有无 N-和 O-连接糖基化的抑制作用，EECs 和 ESCs 的活力，以及 CD44 表面密度的表达情况。使用衣霉素和/或 B-GalNAc 抑制 CD44 的 N-和 O-连接糖基化，统计学上显著抑制了子宫内膜细胞与腹膜间皮细胞的附着，表明其在早期子宫内膜异位症病变的建立中起作用。
