脑和行为的男性化控制。
Control of masculinization of the brain and behavior.
机构信息
Program in Neuroscience, University of California, San Francisco, MC2722, San Francisco, CA 94158, USA.
出版信息
Curr Opin Neurobiol. 2011 Feb;21(1):116-23. doi: 10.1016/j.conb.2010.09.014. Epub 2010 Oct 20.
Abstract
Sex steroid hormones exert a profound influence on the sexual differentiation and function of the neural circuits that mediate dimorphic behaviors. Both estrogen and testosterone are essential for male typical behaviors in many species. Recent studies with genetically modified mice provide important new insights into the logic whereby these two hormones coordinate the display of sexually dimorphic behaviors: estrogen sets up the masculine repertoire of sexual and territorial behaviors and testosterone controls the extent of these male displays.
摘要
性甾体激素对介导二态行为的神经回路的性分化和功能有深远影响。在许多物种中，雌激素和睾丸激素对雄性典型行为都是必不可少的。最近使用基因修饰小鼠进行的研究为这两种激素协调显示二态行为的逻辑提供了重要的新见解：雌激素设定了性行为和领地行为的雄性行为范围，而睾丸激素控制这些雄性表现的程度。
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