University of Vermont College of Medicine, Burlington, USA.
J Am Acad Child Adolesc Psychiatry. 2010 Nov;49(11):1105-16. doi: 10.1016/j.jaac.2010.08.006.
Using a general population sample, the adult outcomes of children who presented with severe problems with self-regulation defined as being concurrently rated highly on attention problems, aggressive behavior, and anxious-depression on the Child Behavior Checklist-Dysregulation Profile (CBCL-DP) were examined.
Two thousand seventy-six children from 13 birth cohorts 4 to 16 years of age were drawn from Dutch birth registries in 1983. CBCLs were completed by parents at baseline when children from the different cohorts were 4 to 16 years of age and sampled every 2 years for the next 14 years. At year 14 the CBCL and DSM interview data were collected. Logistic regression was used to compare and contrast outcomes for children with and without dysregulation, as measured by the latent-class-defined CBCL-DP. Sex and age were covaried and concurrent DSM diagnoses were included in regression models.
Presence of childhood CBCL-DP at wave 1 was associated with increased rates of adult anxiety disorders, mood disorders, disruptive behavior disorders, and drug abuse 14 years later. After controlling for co-occurring disorders in adulthood, associations with anxiety and disruptive behavior disorders with the CBCL-DP remained, whereas the others were not significant.
A child reported to be in the CBCL-DP class is at increased risk for problems with regulating affect, behavior, and cognition in adulthood.
利用一般人群样本，研究被同时评定为注意力问题、攻击性行为和焦虑抑郁程度高的自我调节严重问题的儿童（根据儿童行为检查表失调剖面图（CBCL-DP））的成年后结果。
从 1983 年荷兰出生登记处抽取了 13 个出生队列的 2076 名 4 至 16 岁的儿童。当不同队列的儿童年龄在 4 至 16 岁时，父母在基线时完成 CBCL，随后每 2 年对其进行 14 年的抽样。在第 14 年，收集 CBCL 和 DSM 访谈数据。使用逻辑回归比较和对比通过潜在类别定义的 CBCL-DP 测量的失调儿童和无失调儿童的结果。性别和年龄被协方差，并在回归模型中纳入了同时发生的 DSM 诊断。
在第 1 波中存在儿童 CBCL-DP 与 14 年后成年期焦虑障碍、心境障碍、破坏性行为障碍和药物滥用的发生率增加有关。在控制成年期同时发生的疾病后，与 CBCL-DP 相关的焦虑和破坏性行为障碍的关联仍然存在，而其他则不显著。
被报告为 CBCL-DP 类别的儿童在成年后调节情感、行为和认知方面出现问题的风险增加。
