Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey.
Diabetes Res Clin Pract. 2011 Jan;91(1):26-31. doi: 10.1016/j.diabres.2010.09.028.
Osteoprotegerin (OPG), a novel soluble member of tumour necrosis factor receptor superfamily, has been shown to link cardiovascular disorders. The aim of this study is to investigate the potential relationship between serum OPG levels, cardiovascular risk factors and metabolic syndrome in a relatively large group of women with previous GDM. In this cross-sectional case-control study, 128 women with previous GDM and 67 age-matched controls were enrolled. Subjects were evaluated for the diagnosis of metabolic syndrome according to the criteria of the American Heart Association (AHA). Fasting glucose, insulin, serum lipids, CRP and OPG were assayed. HOMA score was calculated. Carotid intima media thickness (IMT) was measured. There was no significant increase in OPG levels in women with previous GDM when compared to controls. On the other hand, women with previous GDM developing metabolic syndrome had higher OPG levels than those without metabolic syndrome and healthy controls. Serum OPG levels were associated with obesity, insulin resistance, serum CRP and carotid IMT. Serum OPG is related to cardiovascular risk factors and metabolic syndrome, and might be involved in the development of cardiovascular disorders in women with previous GDM.
骨保护素（OPG）是肿瘤坏死因子受体超家族的一种新型可溶性成员，已被证明与心血管疾病有关。本研究旨在探讨先前患有 GDM 的女性中，血清 OPG 水平与心血管危险因素和代谢综合征之间的潜在关系。在这项横断面病例对照研究中，共纳入了 128 名先前患有 GDM 的女性和 67 名年龄匹配的对照组。根据美国心脏协会（AHA）的标准，对受试者进行代谢综合征的诊断评估。检测空腹血糖、胰岛素、血清脂质、CRP 和 OPG。计算 HOMA 评分。测量颈动脉内膜中层厚度（IMT）。与对照组相比，先前患有 GDM 的女性的 OPG 水平没有明显升高。另一方面，患有代谢综合征的先前患有 GDM 的女性的 OPG 水平高于没有代谢综合征的女性和健康对照组。血清 OPG 水平与肥胖、胰岛素抵抗、血清 CRP 和颈动脉 IMT 有关。血清 OPG 与心血管危险因素和代谢综合征有关，可能与先前患有 GDM 的女性心血管疾病的发生有关。
