Division of Cardiac Surgery, University of Maryland Medical Center, Baltimore, Maryland 21201, USA.
Ann Thorac Surg. 2010 Nov;90(5):1401-8, 1410.e1; discussion 1408-10. doi: 10.1016/j.athoracsur.2010.05.055.
The purpose of this study was to examine utilization and outcomes of less-invasive mitral valve (LIMV) operations in North America.
Between 2004 and 2008, 28,143 patients undergoing isolated mitral valve (MV) operations were identified in The Society of Thoracic Surgeons Adult Cardiac Surgical Database (STS ACSD). The LIMV operations were defined as those performed with femoral arterial and venous cannulation.
The LIMV operations increased from 11.9% of MV operations in 2004 to 20.1% in 2008 (p < 0.0001). In 2008, 26% of STS ACSD centers performed at least one LIMV operation, with a median of 3 per year. Patients in the LIMV group were younger and had fewer comorbidities. Median perfusion (135 versus 108 minutes) and cross-clamp times (100 versus 80 minutes, p < 0.0001) were longer in the LIMV group. Mitral valve repair rates were higher in the LIMV group (85% versus 67%, p < 0.0001). Adjusted operative mortality was similar (odds ratio 1.13, 95% confidence interval: 0.84 to 1.51, p = 0.47). Blood transfusion was less common (odds ratio 0.86, 95% confidence interval: 0.76 to 0.97, p < 0.0001) while stroke was more common (OR 1.96, 95% confidence interval: 1.46 to 2.63, p < 0.0001) in the LIMV group.
In selected patients, LIMV operations can be performed with equivalent operative mortality, shorter hospital stay, fewer blood transfusions, and higher rates of MV repair than conventional sternotomy. However, perfusion and cross-clamp times were longer, and the risk of stroke was significantly higher. Beating- or fibrillating-heart LIMV techniques are associated with particularly high risks for perioperative stroke.
本研究旨在考察北美地区微创二尖瓣(LIMV)手术的应用和结果。
2004 年至 2008 年,在胸外科医师学会成人心脏外科学数据库(STS ACSD)中确定了 28143 例接受单纯二尖瓣(MV)手术的患者。LIMV 手术定义为通过股动脉和股静脉插管进行的手术。
LIMV 手术的比例从 2004 年的 MV 手术的 11.9%增加到 2008 年的 20.1%(p < 0.0001)。2008 年,STS ACSD 中心中有 26%至少进行了一次 LIMV 手术,每年中位数为 3 例。LIMV 组患者年龄较小,合并症较少。LIMV 组的中位灌注时间(135 分钟对 108 分钟,p < 0.0001)和体外循环时间(100 分钟对 80 分钟,p < 0.0001)较长。LIMV 组的二尖瓣修复率较高(85%对 67%,p < 0.0001)。调整后的手术死亡率相似(比值比 1.13,95%置信区间:0.84 至 1.51,p = 0.47)。LIMV 组输血较少(比值比 0.86,95%置信区间:0.76 至 0.97,p < 0.0001),而 LIMV 组卒中更常见(比值比 1.96,95%置信区间:1.46 至 2.63,p < 0.0001)。
在选择的患者中,与传统胸骨切开术相比,LIMV 手术可实现等效的手术死亡率、更短的住院时间、更少的输血和更高的二尖瓣修复率。然而,体外循环和主动脉阻断时间较长,卒中风险显著增加。跳动或纤颤心脏 LIMV 技术与围手术期卒中的风险特别高相关。