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姑息性放疗在骨转移中的应用。

The use of palliative radiotherapy for bone metastasis.

机构信息

Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Canada.

出版信息

Radiother Oncol. 2010 Dec;97(3):548-53. doi: 10.1016/j.radonc.2010.09.015.

Abstract

BACKGROUND

The value of palliative radiotherapy (PRT) for bone metastases is well established, but little is known about its use in the general population.

PURPOSE

To describe the use of PRT for bone metastases in Ontario.

MATERIALS AND METHODS

This was a retrospective cohort study. Treatment records from all Ontario RT departments were linked to a population-based cancer registry to describe the use of PRT.

RESULTS

12.2% of the 434,241 patients, who died of cancer in Ontario between 1984 and 2004, received at least one course of PRT for bone metastases in the last 2 years of life. The rate of use of PRT varied across the province (inter-county range, 8.2-18.6%). Older patients and residents of poorer areas were less likely to receive PRT (p<0.0001). Patients diagnosed with cancer in a hospital with a radiotherapy facility and those who lived closer to a radiotherapy centre were more likely to receive PRT (p<0.0001). Over the study period, the use of PRT decreased in breast cancer and myeloma, but increased in prostate cancer (p<0.0001).

CONCLUSIONS

Access to PRT appears to be inequitable. More effort is required to make this useful treatment available to all those who would benefit from it.

摘要

背景

姑息性放射治疗(PRT)在治疗骨转移方面的价值已得到充分证实,但对于其在普通人群中的应用却知之甚少。

目的

描述安大略省骨转移患者接受 PRT 的情况。

材料和方法

这是一项回顾性队列研究。将所有安大略省放射治疗部门的治疗记录与基于人群的癌症登记处进行了关联,以描述 PRT 的使用情况。

结果

1984 年至 2004 年间,在安大略省死于癌症的 434241 名患者中,有 12.2%的患者在生命的最后 2 年内至少接受过一次 PRT 治疗骨转移。全省 PRT 的使用率存在差异(县际差异为 8.2-18.6%)。年龄较大的患者和贫困地区的居民接受 PRT 的可能性较小(p<0.0001)。在有放疗设施的医院诊断出癌症的患者以及居住在离放疗中心较近的患者更有可能接受 PRT(p<0.0001)。在研究期间,乳腺癌和骨髓瘤患者接受 PRT 的比例下降,但前列腺癌患者的接受比例上升(p<0.0001)。

结论

PRT 的应用似乎存在不公平现象。需要付出更多努力,使所有受益于 PRT 的患者都能获得这种有效的治疗方法。

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