富血小板血浆对尼古丁损害骨愈合兔模型的影响
Effect of platelet-rich plasma on a rabbit model of nicotine-compromised bone healing.
作者信息
Ma Li, Zheng Li Wu, Sham Mai Har, Lam Chun Kit, Zwahlen Roger A, Cheung Lim Kwong
机构信息
Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
出版信息
J Oral Maxillofac Surg. 2011 Jan;69(1):28-35. doi: 10.1016/j.joms.2010.05.007. Epub 2010 Oct 25.
PURPOSE
This study aimed to evaluate the effects of platelet-rich plasma (PRP) on nicotine-compromised bone healing.
MATERIALS AND METHODS
Fifteen adult New Zealand white rabbits were implanted with 1.5-g time-release nicotine pellets. Bilateral mandibular distraction osteogenesis was then performed. Autologous PRP was injected into 1 side of the distraction regenerate, whereas physiologic saline solution was injected into the contralateral side as a control. Five rabbits were killed on day 5 of active distraction, on day 11 of active distraction, and in week 2 of consolidation, respectively.
RESULTS
In the PRP the platelet enrichment was 14.63 ± 3.081-fold of that in whole blood. Plain radiography and micro-computed tomography assessment showed no significant difference between the PRP injection and control sides. Histologic examination showed more disorganized distraction tissue on the PRP injection side.
CONCLUSIONS
PRP injection at an early stage of active distraction does not significantly enhance bone healing in the nicotine-compromised rabbit model of mandibular lengthening.
目的
本研究旨在评估富血小板血浆（PRP）对尼古丁损害的骨愈合的影响。
材料与方法
对15只成年新西兰白兔植入1.5克缓释尼古丁丸。然后进行双侧下颌骨牵张成骨。将自体PRP注射到牵张再生区的一侧，而将生理盐溶液注射到对侧作为对照。分别在主动牵张第5天、主动牵张第11天和巩固期第2周处死5只兔子。
结果
PRP中的血小板富集是全血中的14.63±3.081倍。X线平片和微计算机断层扫描评估显示PRP注射侧和对照侧之间无显著差异。组织学检查显示PRP注射侧的牵张组织更紊乱。
结论
在尼古丁损害的下颌骨延长兔模型中，主动牵张早期注射PRP并不能显著促进骨愈合。
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