Zheng Li Wu, Cheung Lim Kwong
Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong, China.
Tissue Eng. 2006 Nov;12(11):3181-8. doi: 10.1089/ten.2006.12.3181.
This study aims to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on mandibular distraction at routine and rapid distraction rates. Eighteen New Zealand white rabbits were assigned to 2 groups, 1 treated at a routine distraction rate (0.9 mm/d) and the other at a rapid distraction rate (2.7 mm/d). rhBMP-2 was injected into 1 side of the distraction regenerate at the end of the active distraction period; the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, microcomputed tomography, and histologic examination. The results showed that rhBMP-2 can promote bone formation at both rapid and routine distraction rates, but no statistically significant difference was observed between the bone morphogenetic protein injection sides of the rapid and routine distraction groups. In conclusion, the study indicates that rhBMP-2 can enhance bone ossification at both routine and rapid distraction rates. The addition of rhBMP-2 seems to be able to compensate for the rapid distraction rate in mandibular distraction osteogenesis. Further longterm follow-up and mechanical strength test for the support of implants or conventional prostheses are necessary.
本研究旨在评估重组人骨形态发生蛋白-2（rhBMP-2）在常规和快速牵张速率下对下颌骨牵张的影响。将18只新西兰白兔分为2组，一组以常规牵张速率（0.9毫米/天）进行治疗，另一组以快速牵张速率（2.7毫米/天）进行治疗。在主动牵张期结束时，将rhBMP-2注射到牵张再生部位的一侧；对侧作为对照。通过X线平片、显微计算机断层扫描和组织学检查对牵张再生部位进行分析。结果表明，rhBMP-2在快速和常规牵张速率下均能促进骨形成，但快速牵张组和常规牵张组的骨形态发生蛋白注射侧之间未观察到统计学上的显著差异。总之，该研究表明rhBMP-2在常规和快速牵张速率下均能增强骨矿化。添加rhBMP-2似乎能够弥补下颌骨牵张成骨中的快速牵张速率。有必要进行进一步的长期随访以及植入物或传统假体支撑的力学强度测试。
