Endocrinology and Nutrition Service, Germans Trias i Pujol Hospital, Badalona, Barcelona, Department of Medicine, Autonomous University of Barcelona, Crta. Canyet s/n, 08916, Badalona, Barcelona, Catalonia, Spain.
Endocrine. 2010 Dec;38(3):391-6. doi: 10.1007/s12020-010-9397-2. Epub 2010 Oct 23.
The prevalence of thyroid dysfunction varies in different populations. The aim of this cross-sectional study was to analyze the prevalence of undiagnosed thyroid dysfunction and thyroid antibodies and their relationship with urine iodine excretion in a representative sample of 1,124 (55.5% women; mean age: 44.8 ± 15.2 years) non-hospitalized Mediterranean adults, in Catalonia (Spain). Free thyroxine, thyroid-stimulating hormone, thyroperoxidase and thyroglobulin antibodies, and urine iodine were measured. Undiagnosed thyroid dysfunction was 5.3% (hypothyroidism 3.8%; 56.66% of these subjects were women). The total (diagnosed + undiagnosed) thyroid dysfunction was 8.9% (71.15% women). Thyroperoxidase antibodies were positive in 2.4% of men and 9.4% of women and thyroglobulin antibodies, in 1.3% of men and 3.8% of women. No differences were observed in urine iodine between groups with thyroid dysfunction and euthyroidism, or between subjects with positive or negative antibodies. In subjects over 60, undiagnosed thyroid dysfunction was 9.8% (hypothyroidism 6.9%, hyperthyroidism 3.3%; 36.36% women) and total thyroid dysfunction 13.61% (53.12% women). Women and men over 60 had similar thyroid dysfunction prevalence. Thus, aggressive case-finding should be recommended in both, over 60.
甲状腺功能障碍的患病率在不同人群中有所不同。本横断面研究旨在分析在 1124 名（55.5%为女性；平均年龄：44.8±15.2 岁）非住院的地中海成年人中，未诊断的甲状腺功能障碍和甲状腺抗体的流行率及其与尿碘排泄的关系，这些成年人来自于加泰罗尼亚（西班牙）。检测游离甲状腺素、促甲状腺激素、甲状腺过氧化物酶和甲状腺球蛋白抗体以及尿碘。未诊断的甲状腺功能障碍为 5.3%（甲状腺功能减退 3.8%；其中 56.66%为女性）。总的（诊断+未诊断）甲状腺功能障碍为 8.9%（71.15%为女性）。男性中有 2.4%和女性中有 9.4%的人甲状腺过氧化物酶抗体阳性，有 1.3%的男性和 3.8%的女性甲状腺球蛋白抗体阳性。甲状腺功能障碍组和甲状腺功能正常组之间或抗体阳性和阴性的组之间，尿碘没有差异。在 60 岁以上的人群中，未诊断的甲状腺功能障碍为 9.8%（甲状腺功能减退 6.9%，甲状腺功能亢进 3.3%；36.36%为女性），总的甲状腺功能障碍为 13.61%（53.12%为女性）。60 岁以上的女性和男性甲状腺功能障碍的患病率相似。因此，建议在 60 岁以上人群中积极进行病例发现。
