Heidarpour Hadise, Hooshmand Farnaz, Isapanah Amlashi Fazel, Khodabakhshi Behnaz, Mahmoudi Mahsa, Amiriani Taghi, Besharat Sima
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.
Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran.
Caspian J Intern Med. 2023 Spring;14(2):371-375. doi: 10.22088/cjim.14.2.371.
Anti-TPO antibodies are one of the characteristic factors in autoimmune thyroiditis (AIT). Previous studies reported a high prevalence of anti-TPO antibodies (Abs) in Iran. We have therefore assessed the prevalence of anti-TPO Abs in Gorgan, Iran.
This cross-sectional study, conducted from 2015 to 2018 in Gorgan city, Northeast of Iran. The Participants included women with Poly cystic ovary syndrome (PCOs), celiac patients, men with hepatitis C infection, and age and sex-matched controls. ELISA method was used for the analysis of laboratory tests.
The number of enrolled subjects in PCOs, celiac disease, and Hepatitis C infection groups were 76, 67, and 60, respectively. Anti-TPO Abs positivity was significantly higher in patients with PCOS than in the control group (18.4% vs. 0.00%; p = 0.000). There were no significant differences in the frequency of anti-TPO Abs positive cases between CD patients and the controls (26.9% vs. 21.1% p =0.413). The incidence of anti-TPO Abs positivity was significantly higher in the control group (10% vs. 25%; P = 0.031).
Very high level of anti-TPO Abs was observed in both patients and healthy population in Golestan province. Considering this rate and its association with autoimmune disorders, it is suggested to prioritize screening programs for related disease in this area.
抗甲状腺过氧化物酶抗体是自身免疫性甲状腺炎（AIT）的特征性因素之一。既往研究报道伊朗抗甲状腺过氧化物酶抗体（Abs）的患病率较高。因此，我们评估了伊朗戈尔甘地区抗甲状腺过氧化物酶抗体的患病率。
这项横断面研究于2015年至2018年在伊朗东北部的戈尔甘市进行。参与者包括多囊卵巢综合征（PCOs）女性、乳糜泻患者、丙型肝炎感染男性以及年龄和性别匹配的对照组。采用酶联免疫吸附测定（ELISA）法进行实验室检测分析。
PCOs组、乳糜泻组和丙型肝炎感染组的入选受试者人数分别为76例、67例和60例。多囊卵巢综合征患者的抗甲状腺过氧化物酶抗体阳性率显著高于对照组（18.4%对0.00%；p = 0.000）。乳糜泻患者和对照组之间抗甲状腺过氧化物酶抗体阳性病例频率无显著差异（26.9%对21.1%，p = 0.413）。对照组抗甲状腺过氧化物酶抗体阳性率显著更高（10%对25%；P = 0.03）。
在戈勒斯坦省的患者和健康人群中均观察到非常高的抗甲状腺过氧化物酶抗体水平。考虑到这一比率及其与自身免疫性疾病的关联，建议优先在该地区开展相关疾病的筛查项目。
