Plewka A, Nowaczyk-Dura G, Czekaj P
II Katedry Histologii i Embriologii Slaskiej Akademii Medycznej w Katowicach.
Folia Med Cracov. 1990;31(3):147-56.
The effects of treatment with phenobarbital, beta-naphthoflavone and dexamethasone on 0,5, 1, 2, 4, 8, 12, 20 and 28 month old male Wistar rats was studied. The animals were treated intraperitoneally with phenobarbital (50 mg/kg; two times), beta-naphthoflavone (20 mg/kg; three times) or dexamethasone (10 mg/kg; three times). The rats were killed and Dallner method hepatic microsomes were isolated. In this fractions the protein by Lowry method and AHH activity according to Gelboin were determined. The AHH activity changes was not observed with age. In all studied animals (with 28 months old rats) phenobarbital inhibited AHH activity. The beta-naphthoflavone markedly increased the AHH activity; particularly in sex maturation and senescent. The dexamethasone injections also increased activity of the enzyme but in young rats only.
研究了苯巴比妥、β-萘黄酮和地塞米松对0、5、1、2、4、8、12、20和28月龄雄性Wistar大鼠的影响。给动物腹腔注射苯巴比妥（50mg/kg；两次）、β-萘黄酮（20mg/kg；三次）或地塞米松（10mg/kg；三次）。处死大鼠，采用达尔纳方法分离肝微粒体。用洛瑞法测定该组分中的蛋白质，根据盖尔博因法测定芳烃羟化酶（AHH）活性。未观察到AHH活性随年龄变化。在所有研究的动物（包括28月龄大鼠）中，苯巴比妥抑制AHH活性。β-萘黄酮显著增加AHH活性；尤其在性成熟和衰老阶段。地塞米松注射也增加了该酶的活性，但仅在幼鼠中。
