Carmichael Suzan L, Rasmussen Sonja A, Shaw Gary M
California Research Division, March of Dimes Foundation, 5700 Martin Luther King, Jr. Way, Oakland, CA 94609, USA.
Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):804-10. doi: 10.1002/bdra.20679.
Obesity is associated with increased risk of many adverse health conditions. During pregnancy, obesity presents particularly important challenges for both mother and baby. Over the last 20 years, studies have emerged indicating an association between prepregnancy weight and risks of birth defects. However, few studies have examined the mechanisms through which this association occurs. Understanding the underlying mechanisms may provide clues to public health strategies for the prevention of birth defects associated with maternal obesity. This article briefly reviews existing literature on the association between maternal obesity and birth defects, discusses potential underlying mechanisms, and suggests research needed to improve our understanding of this important association.
肥胖与许多不良健康状况风险增加相关。在孕期，肥胖对母亲和婴儿都构成了尤为重大的挑战。在过去20年里，有研究表明孕前体重与出生缺陷风险之间存在关联。然而，很少有研究探讨这种关联产生的机制。了解潜在机制可能为预防与母体肥胖相关的出生缺陷的公共卫生策略提供线索。本文简要回顾了关于母体肥胖与出生缺陷关联的现有文献，讨论了潜在的潜在机制，并提出了为增进我们对这一重要关联的理解所需开展的研究。
