Department of Paediatric Haematology and Oncology, University of Catania, Catania, Italy.
Pediatr Blood Cancer. 2011 Feb;56(2):298-300. doi: 10.1002/pbc.22807.
We report the case of a child presenting with concurrent thoracic ganglioneuroblastoma and acute myeloid leukemia. The peculiarity was the close relation between the two tumors with the latter infiltrating the former one. Histological and genomic studies indicate the different clonal origins of the malignancies in the patient, and we hypothesized that GNB and AML developed independently. Our observation suggests that in patients with more than one tumor, though discovered at different times, one neoplasm is not always secondary.
我们报告了一例同时患有胸神经节母细胞瘤和急性髓系白血病的儿童病例。其特点是两种肿瘤关系密切，后者浸润了前者。组织学和基因组研究表明患者的两种恶性肿瘤具有不同的克隆起源，我们推测 GNB 和 AML 是独立发展的。我们的观察结果表明，在同时患有多种肿瘤的患者中，即使这些肿瘤是在不同时间发现的，也并非总是一种肿瘤是另一种肿瘤的继发瘤。
