Moss T J, Strauss L C, Das L, Feig S A
Gwynne Hazen Cherry Memorial Laboratory, Jonsson Cancer Center, UCLA School of Medicine, Department of Pediatrics 90024.
Am J Pediatr Hematol Oncol. 1989 Summer;11(2):158-61.
Leukemia accounts for 15-20% of the secondary malignancies among survivors of Wilms' tumor. We report three patients who developed leukemia after the successful treatment of Wilms' tumor, each of whom demonstrates the importance of close long-term medical surveillance. The first patient developed Philadelphia chromosome positive chronic myelogenous leukemia (CML) 6 years after the diagnosis of Wilms' tumor. This is the second report of CML occurring after Wilms' tumor. The other two patients developed acute nonlymphocytic leukemia (ANLL) 3 and 18 years after successful treatment of Wilms' tumor. In one patient, the clinical manifestations were subtle, and in the other the latency period was the longest reported for secondary leukemia following Wilms' tumor. We conclude that survivors of childhood cancer require frequent medical surveillance even in their adult years.
白血病在肾母细胞瘤幸存者继发的恶性肿瘤中占15% - 20%。我们报告了3例在肾母细胞瘤成功治疗后发生白血病的患者，每例患者都显示了长期密切医学监测的重要性。首例患者在肾母细胞瘤诊断6年后发生费城染色体阳性慢性粒细胞白血病（CML）。这是肾母细胞瘤后发生CML的第二例报告。另外2例患者在肾母细胞瘤成功治疗后3年和18年发生急性非淋巴细胞白血病（ANLL）。1例患者临床表现不明显，另1例患者的潜伏期是肾母细胞瘤后继发性白血病报告中最长的。我们得出结论，儿童癌症幸存者即使在成年后也需要频繁的医学监测。
