Tokoro T, Funata M, Akazawa Y
Department of Ophthalmology, Tokyo Medical and Dental University School of Medicine, Japan.
J Ocul Pharmacol. 1990 Winter;6(4):285-91. doi: 10.1089/jop.1990.6.285.
The role of intraocular pressure (IOP) on axial elongation was studied by the following three experiments. 1) Thickness of the sclera in the lid-sutured-myopia of three monkeys was examined by light microscopy. The sclera of the experimental eye in the posterior pole was thinner than that of the control eye, but no differences were found in the equatorial and limbal parts of the sclera. 2) By increasing IOP, the scleral wall extensibility in 8 normal, enucleated rabbit eyes was measured by placing the foil strain gauges on the sclera. Extensibility of the sclera in the posterior pole showed a different response from that at the equator and in the limbus. 3) IOPs of the 184 human myopic eyes were measured by a Mackay-Marg tonometer in various postures. IOP elevations in high myopia and postural variations of IOP were obtained. From these experiments, it was suggested that IOP seemed to be one of the main factors in increasing the axis to the posterior pole.
通过以下三个实验研究了眼内压（IOP）对眼轴伸长的作用。1）通过光学显微镜检查了三只猴子眼睑缝合性近视模型中巩膜的厚度。实验眼后极部的巩膜比对照眼薄，但在巩膜的赤道部和角膜缘部未发现差异。2）通过增加眼内压，将箔式应变片置于巩膜上，测量了8只正常摘除的兔眼巩膜壁的伸展性。后极部巩膜的伸展性与赤道部和角膜缘部表现出不同的反应。3）用麦凯-玛格眼压计测量了184只人类近视眼睛在不同姿势下的眼压。得出了高度近视患者的眼压升高情况以及眼压的姿势变化情况。从这些实验中可以看出，眼内压似乎是导致眼轴向后极部增长的主要因素之一。
