Shih Y F, Yang C M, Lin S Y, Huang J S, Lin L L, Hung P T
Department of Ophthalmology, National Taiwan University Hospital, Taipei.
Optom Vis Sci. 1998 Oct;75(10):758-62. doi: 10.1097/00006324-199810000-00021.
To study whether lid suturing can induce axial myopia and explore whether trans-scleral cryotherapy can affect ocular growth in piglets or not.
A total of fourteen 2- to 3-week-old piglets were studied. Three groups were included: lid suture, cryotherapy, and both lid suture/cryotherapy groups. The lid suturing group (N = 6) was given lid suturing to produce visual deprivation. The cryotherapy group (N = 4) received trans-scleral cryotherapy 360 degrees to encircle anterior to the equator. Both treatment groups (N = 4) received both cryotherapy and lid suturing. The cycloplegic refraction, corneal power, biometric axial length, and intraocular pressure (IOP) were measured before the experiments and 4 months later.
Mild axial myopia was induced in five lid-sutured eyes of the lid suturing group. The ocular refraction and eye size of cryotherapy eyes were not different from the control eyes in the cryotherapy group. More myopia was found in all four piglets that received both cryotherapy and lid suturing.
Lid suturing can induce axial myopia; however, cryotherapy did not affect normal eye growth and did not prevent the development of lid suturing myopia in piglets.
研究眼睑缝合是否能诱发轴性近视，并探讨经巩膜冷冻疗法是否会影响仔猪的眼球生长。
共研究了14只2至3周龄的仔猪。分为三组：眼睑缝合组、冷冻疗法组和眼睑缝合/冷冻疗法联合组。眼睑缝合组（N = 6）进行眼睑缝合以造成视觉剥夺。冷冻疗法组（N = 4）接受360度经巩膜冷冻疗法，环绕赤道前方。联合治疗组（N = 4）同时接受冷冻疗法和眼睑缝合。在实验前和4个月后测量睫状肌麻痹验光、角膜屈光力、生物测量眼轴长度和眼压（IOP）。
眼睑缝合组的5只眼睑缝合眼中诱发了轻度轴性近视。冷冻疗法组中，接受冷冻疗法的眼睛的眼屈光和眼大小与对照眼无差异。在接受冷冻疗法和眼睑缝合的所有4只仔猪中发现了更多近视。
眼睑缝合可诱发轴性近视；然而，冷冻疗法并未影响仔猪正常的眼球生长，也未阻止眼睑缝合性近视的发展。
