Urano S, Kitahara M, Kato Y, Hasegawa Y, Matsuo M
Tokyo Metropolitan Institute of Gerontology, Japan.
J Nutr Sci Vitaminol (Tokyo). 1990 Dec;36(6):513-9. doi: 10.3177/jnsv.36.513.
In order to elucidate the existence of a hydrogen bond between alpha-tocopherol and phospholipids in bilayer liposomes, the effects of the presence or absence of alpha-tocopherol or its acetate on either the permeability of liposomes to chromate ions or the fluidity of liposomes composed of the different kinds of lecithin [egg yolk phosphatidylcholine (EPC), 1-oleoyl-2-palmitoylphosphatidylcholine (OPPC), or 1-O-oleyl-2-O-palmitoylphosphatidylcholine (OPPCE)] were examined. From the results obtained, it was concluded that the hydroxyl group of alpha-tocopherol is hydrogen bonded to the carbonyl group of a fatty acid ester in the phospholipids of bilayer liposomes in order to retain alpha-tocopherol molecule in the space close to the surface of membranes formed by the unsaturated fatty acid moiety of phospholipids.
为了阐明双层脂质体中α-生育酚与磷脂之间氢键的存在，研究了α-生育酚或其乙酸酯的存在与否对脂质体对铬酸根离子的通透性或由不同种类卵磷脂[蛋黄磷脂酰胆碱（EPC）、1-油酰基-2-棕榈酰磷脂酰胆碱（OPPC）或1-O-油酰基-2-O-棕榈酰磷脂酰胆碱（OPPCE）]组成的脂质体流动性的影响。根据所得结果得出结论，α-生育酚的羟基与双层脂质体磷脂中脂肪酸酯的羰基形成氢键，以便将α-生育酚分子保留在由磷脂不饱和脂肪酸部分形成的膜表面附近的空间中。
