Verma S K, Dosi R, Kaushik S K, Bordia A
Department of Medicine (Cardiology), R.N.T. Medical College, Udaipur.
J Postgrad Med. 1990 Jan;36(1):5-8.
Thirty patients with diastolic blood pressure of 120 mm Hg or more were administered a bolus dose of verapamil (0.15 mg/kg) followed immediately by an intravenous infusion at a rate of 0.005 mg/kg/min for one hour. The patients were monitored during this period and three hours following the discontinuation of the infusion. The systolic, diastolic and mean blood pressures before verapamil administration were 221.4 +/- 7.5, 134.3 +/- 2.7 and 163.4 +/- 4.1 mm Hg respectively, which decreased to 170.1 +/- 5.2, 99.1 +/- 3.7 and 122.8 +/- 3.6 mm Hg after intravenous bolus of verapamil. The fall in all the levels of blood pressure was significant (p less than 0.001) and was maintained at the lower levels throughout the infusion period and even three hours after discontinuation of the therapy. No untowards effects were observed and there was no significant change in heart rate and electrocardiogram. It, thus, proves to be an useful addition to the therapeutic armamentarium in the acute management of severe hypertension.
30名舒张压在120毫米汞柱及以上的患者被给予一剂维拉帕米（0.15毫克/千克）静脉推注，随后立即以0.005毫克/千克/分钟的速率静脉输注一小时。在此期间及输注停止后的三小时内对患者进行监测。维拉帕米给药前的收缩压、舒张压和平均血压分别为221.4±7.5、134.3±2.7和163.4±4.1毫米汞柱，静脉推注维拉帕米后分别降至170.1±5.2、99.1±3.7和122.8±3.6毫米汞柱。所有血压水平的下降均具有显著性（p＜0.001），并且在整个输注期间以及治疗停止后的三小时内均维持在较低水平。未观察到不良影响，心率和心电图也无显著变化。因此，它被证明是严重高血压急性管理治疗手段中的一项有益补充。
