Zaslavskaia R M, Vilkovyskiĭ F A, Goncharov L F
Kardiologiia. 1990 Dec;30(12):11-3.
In 96 patients with coronary heart disease and stage II circulatory failure, the chronopharmacodynamics of strophanthin, corglycon, and nitrosorbide was studied by using acute clinical and pharmacological tests in the morning (8.00 a.m.), in the afternoon (2.00 p.m.), and in the evening (8.00 p.m.). Central and peripheral hemodynamic parameters were measured prior to and following 5, 15, 30, 60, and 120 min of intravenous injection of cardiac glycosides or sublingual administration of nitrosorbide in a dose of 10 mg for 240 min. The investigations showed that there were the most profound hemodynamic changes in the morning if strophanthin was used and in the afternoon if corglycon was given. The maximal reduction in heart pre- and afterload was seen in the morning when nitrosorbide was applied, the most improvement in central hemodynamic parameters was observed in the evening when nitrosorbide was used.
对96例冠心病伴II期循环衰竭患者，通过在上午8点、下午2点和晚上8点进行急性临床和药理学试验，研究了毒毛花苷、毛花强心苷和硝酸异山梨酯的时辰药效学。在静脉注射强心苷或舌下含服10 mg硝酸异山梨酯240分钟前及注射后5、15、30、60和120分钟，测量中心和外周血流动力学参数。研究表明，使用毒毛花苷时上午血流动力学变化最显著，使用毛花强心苷时下午变化最显著。应用硝酸异山梨酯时，上午心脏前负荷和后负荷的最大降低出现，使用硝酸异山梨酯时，晚上中心血流动力学参数改善最为明显。
