Morozova T E
Kardiologiia. 1990 Dec;30(12):13-5.
The study was undertaken to examine the effects of prazosin on clinical manifestations of the disease, hemodynamic parameters and myocardial contractility in 33 patients with coronary heart disease, postinfarction cardiosclerosis. The study was performed during an acute and chronic drug test. The efficiency of the therapy was checked by conventional clinical tools and examination of hemodynamic parameters and myocardial contractility from echocardiographic evidence. In the acute and chronic drug test, prazosin was found to cause a significant reduction in systemic and pulmonary pressures, total peripheral resistance and an improvement of total and regional myocardial contractility. Its two- or three-week therapy suffices to achieve the steady therapeutic effect of the drug.
本研究旨在探讨哌唑嗪对33例冠心病、心肌梗死后心肌硬化患者的疾病临床表现、血流动力学参数及心肌收缩力的影响。研究在急性和慢性药物试验期间进行。通过传统临床工具以及根据超声心动图证据检查血流动力学参数和心肌收缩力来检验治疗效果。在急性和慢性药物试验中，发现哌唑嗪可使体循环和肺循环压力、总外周阻力显著降低，并使整体和局部心肌收缩力得到改善。其为期两周或三周的治疗足以实现该药物的稳定治疗效果。
