Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.
Hum Immunol. 2011 Feb;72(2):107-14. doi: 10.1016/j.humimm.2010.10.012. Epub 2010 Nov 4.
Gene profile analysis of ILT3-Fc-induced Ts revealed a significant upregulation of Zink finger proteins, most of which act as transcriptional repressors. Included among these repressors is BCL6, which was shown to play a critical role in the differentiation of ILT3-Fc-induced T suppressor (Ts) cells. Genes implicated in cell cycle progression were downregulated. Genes encoding numerous inflammatory cytokines and chemokines were also downregulated. In contrast, antiapoptotic genes, as well as members of the WNT and transforming growth factor-β pathways, were upregulated. This study elucidates certain important aspects of Ts differentiation and function.
ILT3-Fc 诱导的 Ts 中基因谱分析显示，锌指蛋白显著上调，其中大多数作为转录抑制因子发挥作用。这些抑制因子中包括 BCL6，它在 ILT3-Fc 诱导的 T 抑制（Ts）细胞分化中起着关键作用。参与细胞周期进展的基因下调。编码许多炎症细胞因子和趋化因子的基因也下调。相反，抗凋亡基因以及 WNT 和转化生长因子-β途径的成员上调。本研究阐明了 Ts 分化和功能的某些重要方面。
