Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, CA 90095, USA.
Am J Obstet Gynecol. 2011 Mar;204(3):230.e1-7. doi: 10.1016/j.ajog.2010.09.018. Epub 2010 Oct 25.
This study was undertaken to determine whether there is familial aggregation of hyperemesis gravidarum (HG), making it a disease amenable to genetic study.
Cases with severe nausea and vomiting in a singleton pregnancy treated with intravenous hydration and unaffected friend controls completed a survey regarding family history.
Sisters of women with HG have a significantly increased risk of having HG themselves (odds ratio, 17.3; P = .005). Cases have a significantly increased risk of having a mother with severe nausea and vomiting; 33% of cases reported an affected mother compared to 7.7% of controls (P < .0001). Cases reported a similar frequency of affected second-degree maternal and paternal relatives (18% maternal lineage, 23% paternal lineage).
There is familial aggregation of HG. This study provides strong evidence for a genetic component to HG. Identification of the predisposing gene(s) may determine the cause of this poorly understood disease of pregnancy.
本研究旨在确定妊娠剧吐(HG)是否存在家族聚集性,使其成为适合遗传研究的疾病。
在接受静脉补液治疗的单胎妊娠中出现严重恶心和呕吐的病例以及未受影响的朋友对照者完成了一项关于家族史的调查。
HG 女性的姐妹自身发生 HG 的风险显著增加(优势比,17.3;P=0.005)。病例发生母亲有严重恶心和呕吐的风险显著增加;33%的病例报告母亲受影响,而对照组为 7.7%(P<0.0001)。病例报告了相似频率的受影响的二级母系和父系亲属(母系 18%,父系 23%)。
HG 存在家族聚集性。本研究为 HG 的遗传成分提供了有力证据。确定易患基因可能会确定这种对妊娠了解甚少的疾病的病因。