Christine E. Lynn Heart and Vascular Institute, Boca Raton, FL, USA.
J Vasc Surg. 2011 Jan;53(1):187-92. doi: 10.1016/j.jvs.2010.08.027. Epub 2010 Oct 25.
The Society for Vascular Surgery® pursued development of clinical practice guidelines for the management of traumatic thoracic aortic injuries with thoracic endovascular aortic repair. In formulating clinical practice guidelines, the Society selected a panel of experts and conducted a systematic review and meta-analysis of the literature. They used the Grading of Recommendations Assessment, Development and Evaluation methods (GRADE) to develop and present their recommendations. The systematic review included 7768 patients from 139 studies. The mortality rate was significantly lower in patients who underwent endovascular repair, followed by open repair, and nonoperative management (9%, 19%, and 46%, respectively, P < .01). Based on the overall very low quality of evidence, the committee suggests that endovascular repair of thoracic aortic transection is associated with better survival and decreased risk of spinal cord ischemia, renal injury, graft, and systemic infections compared with open repair or nonoperative management (Grade 2, Level C). The committee was also surveyed on a variety of issues that were not specifically addressed by the meta-analysis. On these select matters, the majority opinions of the committee suggest urgent repair following stabilization of other injuries, observation of minimal aortic defects, selective (vs routine) revascularization in cases of left subclavian artery coverage, and that spinal drainage is not routinely required in these cases.
美国血管外科学会®致力于制定胸主动脉创伤性损伤的管理临床实践指南,包括胸主动脉腔内修复术。在制定临床实践指南时,该学会选择了一组专家,并对文献进行了系统回顾和荟萃分析。他们使用推荐评估、制定和评估方法(GRADE)来制定和呈现他们的建议。系统回顾包括来自 139 项研究的 7768 名患者。接受血管内修复的患者死亡率明显较低,其次是开放修复和非手术治疗(分别为 9%、19%和 46%,P<0.01)。基于总体证据质量非常低,委员会建议与开放修复或非手术治疗相比,胸主动脉横断伤的血管内修复与更好的生存和降低脊髓缺血、肾脏损伤、移植物和全身感染的风险相关(2 级,C 级)。委员会还就荟萃分析未具体涉及的各种问题进行了调查。在这些选定的问题上,委员会的多数意见建议在稳定其他损伤后进行紧急修复,观察最小的主动脉缺陷,选择性(而非常规)对左锁骨下动脉覆盖的病例进行再血管化,并且在这些情况下通常不需要脊柱引流。