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Structural and biological properties of the Drosophila insulin-like peptide 5 show evolutionary conservation.果蝇胰岛素样肽 5 的结构和生物学特性表现出进化上的保守性。
J Biol Chem. 2011 Jan 7;286(1):661-73. doi: 10.1074/jbc.M110.156018. Epub 2010 Oct 25.
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Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans.果蝇和人类胰岛素/IGF 信号轴在胰岛素受体水平的结构保守性。
Nat Commun. 2023 Oct 7;14(1):6271. doi: 10.1038/s41467-023-41862-x.
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Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.人胰岛素中与糖尿病相关的突变：和歌山α链变体胰岛素的晶体结构与光交联研究
Biochemistry. 2005 Apr 5;44(13):5000-16. doi: 10.1021/bi047585k.
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Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain.胰岛素的手性诱变。折叠能力和功能由B链中的立体特异性开关反向调节。
Biochemistry. 2005 Apr 5;44(13):4984-99. doi: 10.1021/bi048025o.
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Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins.通过立体特异性去折叠增强蛋白质活性：胰岛素的构象生命周期及其进化起源
J Biol Chem. 2009 May 22;284(21):14586-96. doi: 10.1074/jbc.M900085200. Epub 2009 Mar 25.
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Protein structure and the spandrels of San Marco: insulin's receptor-binding surface is buttressed by an invariant leucine essential for its stability.蛋白质结构与圣马可教堂的拱肩：胰岛素的受体结合表面由一个对其稳定性至关重要的不变亮氨酸支撑。
Biochemistry. 2002 Jan 22;41(3):809-19. doi: 10.1021/bi011839+.
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dSmad2 differentially regulates dILP2 and dILP5 in insulin producing and circadian pacemaker cells in unmated adult females.dSmad2 在未交配成年雌蝇的胰岛素分泌细胞和生物钟起搏细胞中差异调节 dILP2 和 dILP5。
PLoS One. 2023 Jan 23;18(1):e0280529. doi: 10.1371/journal.pone.0280529. eCollection 2023.
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Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions.基于结构的胰岛素治疗蛋白组装体稳定化：通过增强芳香族-芳香族相互作用。
J Biol Chem. 2018 Jul 13;293(28):10895-10910. doi: 10.1074/jbc.RA118.003650. Epub 2018 Jun 7.
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How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.胰岛素的结合方式：B链α螺旋与胰岛素受体的L1β螺旋接触。
J Mol Biol. 2004 Aug 6;341(2):529-50. doi: 10.1016/j.jmb.2004.05.023.
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Solution structure of the B-chain of insulin as determined by 1H NMR spectroscopy. Comparison with the crystal structure of the insulin hexamer and with the solution structure of the insulin monomer.通过1H核磁共振光谱法测定的胰岛素B链的溶液结构。与胰岛素六聚体的晶体结构以及胰岛素单体的溶液结构的比较。
Int J Pept Protein Res. 1995 Nov;46(5):424-33. doi: 10.1111/j.1399-3011.1995.tb01077.x.
引用本文的文献
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Synthetic studies of the mutant proinsulin syndrome demonstrate correlation between folding efficiency and age of diabetes onset.突变胰岛素原综合征的合成研究表明折叠效率与糖尿病发病年龄之间存在相关性。
Int J Pept Res Ther. 2025 Jan;31(1). doi: 10.1007/s10989-024-10665-z. Epub 2024 Nov 20.
2
Gene model for the ortholog of in .在……中该直系同源基因的基因模型。
MicroPubl Biol. 2024 Dec 8;2024. doi: 10.17912/micropub.biology.000782. eCollection 2024.
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Sustained antiviral insulin signaling during West Nile virus infection results in viral mutations.西尼罗河病毒感染期间持续的抗病毒胰岛素信号传导会导致病毒突变。
Front Cell Infect Microbiol. 2024 Nov 27;14:1492403. doi: 10.3389/fcimb.2024.1492403. eCollection 2024.
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Insulin Resistance: The Increased Risk of Cancers.胰岛素抵抗：癌症风险增加。
Curr Oncol. 2024 Feb 13;31(2):998-1027. doi: 10.3390/curroncol31020075.
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Biochemical characterization of the Drosophila insulin receptor kinase and longevity-associated mutants.果蝇胰岛素受体激酶的生化特性及其与寿命相关的突变体。
FASEB J. 2024 Jan;38(1):e23355. doi: 10.1096/fj.202301948R.
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Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans.果蝇和人类胰岛素/IGF 信号轴在胰岛素受体水平的结构保守性。
Nat Commun. 2023 Oct 7;14(1):6271. doi: 10.1038/s41467-023-41862-x.
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Reinstated Activity of Human Tau-induced Enhanced Insulin Signaling Restricts Disease Pathogenesis by Regulating the Functioning of Kinases/Phosphatases and Tau Hyperphosphorylation in Drosophila.人 Tau 诱导的增强胰岛素信号恢复活性通过调节果蝇中激酶/磷酸酶的功能和 Tau 过度磷酸化来限制疾病发病机制。
Mol Neurobiol. 2024 Feb;61(2):982-1001. doi: 10.1007/s12035-023-03599-y. Epub 2023 Sep 7.
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Identification, Synthesis, Conformation and Activity of an Insulin-like Peptide from a Sea Anemone.一种海葵胰岛素样肽的鉴定、合成、构象和活性
Biomolecules. 2021 Nov 29;11(12):1785. doi: 10.3390/biom11121785.
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Insects as a New Complex Model in Hormonal Basis of Obesity.昆虫作为肥胖症激素基础的新型复杂模型。
Int J Mol Sci. 2021 Oct 14;22(20):11066. doi: 10.3390/ijms222011066.
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Insulin-Like Peptides and Cross-Talk With Other Factors in the Regulation of Insect Metabolism.胰岛素样肽与昆虫代谢调控中其他因子的相互作用
Front Physiol. 2021 Jun 29;12:701203. doi: 10.3389/fphys.2021.701203. eCollection 2021.
本文引用的文献
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[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.[27] 用于多同晶置换和多波长反常衍射方法的最大似然重原子参数精修
Methods Enzymol. 1997;276:472-494. doi: 10.1016/S0076-6879(97)76073-7.
2
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.胰岛素受体串联激素结合元件的结构解析及其对肽类激动剂设计的意义。
Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6771-6. doi: 10.1073/pnas.1001813107. Epub 2010 Mar 26.
3
Molecular evolution and functional characterization of Drosophila insulin-like peptides.果蝇胰岛素样肽的分子进化与功能特征。
PLoS Genet. 2010 Feb 26;6(2):e1000857. doi: 10.1371/journal.pgen.1000857.
4
Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin.G0/G1 期同步增强了过表达人胰岛素受体 A 异构体的细胞对胰岛素的有丝分裂反应。
Cell Biol Toxicol. 2010 Aug;26(4):293-307. doi: 10.1007/s10565-009-9142-x. Epub 2009 Nov 8.
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HYDROGEN ION CONCENTRATIONS IN THE BLOOD OF INSECTS.昆虫血液中的氢离子浓度。
J Gen Physiol. 1925 May 20;7(5):599-602. doi: 10.1085/jgp.7.5.599.
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Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins.盲鳗和七鳃鳗胰岛素异常受体结合特性的结构基础。
Biochemistry. 2009 Dec 1;48(47):11283-95. doi: 10.1021/bi901269j.
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Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation.胰岛素和IGF1受体变构结合与激活的谐振子模型
Mol Syst Biol. 2009;5:243. doi: 10.1038/msb.2008.78. Epub 2009 Feb 17.
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High-affinity insulin binding: insulin interacts with two receptor ligand binding sites.高亲和力胰岛素结合：胰岛素与两个受体配体结合位点相互作用。
Biochemistry. 2008 Dec 2;47(48):12900-9. doi: 10.1021/bi801693h.
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A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.基于系统发育信息的胰岛素受体家族胞外域的比较结构生物信息学分析。
PLoS One. 2008;3(11):e3667. doi: 10.1371/journal.pone.0003667. Epub 2008 Nov 7.
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The insulin receptor: a prototype for dimeric, allosteric membrane receptors?胰岛素受体：二聚体变构膜受体的原型？
Trends Biochem Sci. 2008 Aug;33(8):376-84. doi: 10.1016/j.tibs.2008.06.003. Epub 2008 Jul 18.
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