De Keyzer Kristel, Van Laecke Steven, Peeters Patrick, Vanholder Raymond
Renal Division, Ghent University Hospital, Ghent, Belgium.
Am J Nephrol. 2010;32(5):491-6. doi: 10.1159/000321328. Epub 2010 Oct 26.
After kidney transplantation, thrombotic microangiopathy (TMA) can occur de novo or as recurrent disease. Risk factors for de novo posttransplant TMA include ischemia-reperfusion injury, immunosuppressive drugs, viral infections, acute humoral rejection, and complement gene abnormalities. Cytomegalovirus infection as a trigger for posttransplant TMA in kidney transplant recipients has only been reported in 7 cases, all of them between 4 weeks and 8 years after transplantation. We describe a new case of de novo TMA in association with cytomegalovirus infection 25 years after kidney transplantation.
肾移植后，血栓性微血管病（TMA）可新发或作为复发性疾病出现。移植后新发TMA的危险因素包括缺血再灌注损伤、免疫抑制药物、病毒感染、急性体液排斥反应和补体基因异常。巨细胞病毒感染作为肾移植受者移植后TMA的触发因素仅在7例病例中被报道过，所有这些病例均发生在移植后4周和8年之间。我们描述了1例肾移植25年后与巨细胞病毒感染相关的新发TMA病例。
