Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Fu Jen Catholic University, New Taipei City, Taiwan.
Transpl Int. 2024 Jan 23;37:12168. doi: 10.3389/ti.2024.12168. eCollection 2024.
thrombotic microangiopathy (TMA) is a rare and challenging condition in kidney transplant recipients, with limited research on its incidence and impact on graft survival. This study conducted a systematic review and meta-analysis of 28 cohorts/single-arm studies and 46 case series/reports from database inception to June 2022. In meta-analysis, among 14,410 kidney allograft recipients, TMA occurred in 3.20% [95% confidence interval (CI): 1.93-4.77], with systemic and renal-limited TMA rates of 1.38% (95% CI: 06.5-2.39) and 2.80% (95% CI: 1.27-4.91), respectively. The overall graft loss rate of TMA was 33.79% (95% CI: 26.14-41.88) in meta-analysis. This study provides valuable insights into the incidence and graft outcomes of TMA in kidney transplant recipients.
血栓性微血管病（TMA）是肾移植受者中一种罕见且具有挑战性的病症，其发病率及其对移植物存活率的影响的相关研究有限。本研究对从数据库建立到 2022 年 6 月为止的 28 个队列/单臂研究和 46 个病例系列/报告进行了系统评价和荟萃分析。在荟萃分析中，在 14410 例肾移植受者中，TMA 的发生率为 3.20%（95%置信区间：1.93-4.77），全身性和肾脏局限性 TMA 的发生率分别为 1.38%（95%置信区间：0.65-2.39）和 2.80%（95%置信区间：1.27-4.91）。TMA 的总体移植物丢失率在荟萃分析中为 33.79%（95%置信区间：26.14-41.88）。本研究为肾移植受者中 TMA 的发病率和移植物结局提供了有价值的见解。
