Interdonato F, Festi L, Gerosa C, Benevento A, Dionigi R
Dipartimento di Chirurgia, Università degli Studi di Pavia.
Minerva Chir. 1990 Nov;45(21-22):1389-92.
With the aim of preventing deep vein thrombosis after radical or modified mastectomy, 100 patients were randomly assigned to one of two different groups: the first group was treated with defibrotide (400 mg b.i.d. e.v.) starting from the day before the operation and continuing for the following seven days. The second group was given calcium heparin (5,000 IU b.i.d. by s.c. route) from day 0 to the 7th post-operative day. Neither side effects nor DVT or PE were observed. The quantity of fluids from the drainages rapidly decreased in both groups from the first day to the third one, while the quantity of blood cells was negligible starting from the second post-operative day. On this basis defibrotide may be considered an effective and well tolerated drug for the prevention of DVT.
为预防根治性或改良根治性乳房切除术后深静脉血栓形成，100例患者被随机分为两组：第一组从手术前一天开始接受去纤苷治疗（静脉注射，每日两次，每次400毫克），并持续七天。第二组从术后第0天至第7天皮下注射钙肝素（每日两次，每次5000国际单位）。未观察到副作用、深静脉血栓形成或肺栓塞。两组引流液量从第一天到第三天迅速减少，而术后第二天开始血细胞数量可忽略不计。在此基础上，去纤苷可被认为是预防深静脉血栓形成的一种有效且耐受性良好的药物。
