Górka Z, Zajaczkowski W
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Pol J Pharmacol Pharm. 1990 Jul-Aug;42(4):313-20.
Effects of the MAO-A-inhibitor brofaromine (BRO), 10 mg/kg po after repeated (twice daily for 14 days) administration on the spontaneous behavior (exploratory and basal locomotor activities) and the exploratory activity modified by methoxamine, clonidine and d-amphetamine in male Wistar rats were studied in both light and dark phases of a diurnal cycle (L: 0700-1900 h). After single administration BRO in the light phase had no effects. In the dark phase BRO decreased the exploration (62% of control, p less than 0.01), increased the clonidine-evoked hypoactivity and amphetamine-evoked hyperactivity. The L-D differences occurred also after repeated administration. BRO in the light phase did not influence the exploration, decreased basal locomotor activity, did not change methoxamine and clonidine action and potentiated the action of amphetamine. In the dark phase, however, it did not influence the exploration and basal locomotor activity, intensified the methoxamine effect, and did not change the clonidine and amphetamine actions. The results demonstrate that the effects of BRO on behavior in rats: 1) differ from the effects caused by other antidepressants which are not MAO inhibitors; 2) are phase-dependent after both single and repeated administration.
研究了单胺氧化酶 A 抑制剂溴法罗明（BRO）在雄性 Wistar 大鼠中重复给药（每日两次，共 14 天），剂量为 10mg/kg 口服后，在昼夜周期的光照和黑暗阶段（L：0700 - 1900h）对自发行为（探索性和基础运动活动）以及由甲氧明、可乐定和 d - 苯丙胺改变的探索性活动的影响。在光照阶段单次给药后，BRO 无作用。在黑暗阶段，BRO 减少探索活动（为对照组的 62%，p < 0.01），增加可乐定诱发的活动减退和苯丙胺诱发的活动亢进。重复给药后也出现了明暗差异。在光照阶段，BRO 不影响探索活动，降低基础运动活动，不改变甲氧明和可乐定的作用，并增强苯丙胺的作用。然而，在黑暗阶段，它不影响探索活动和基础运动活动，增强甲氧明的作用，不改变可乐定和苯丙胺的作用。结果表明，BRO 对大鼠行为的影响：1）不同于其他非单胺氧化酶抑制剂的抗抑郁药所引起的影响；2）单次和重复给药后均具有时相依赖性。
