Zajaczkowski W, Górka Z
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Pol J Pharmacol. 1993 Mar-Apr;45(2):157-66.
In this paper the effects of single and repeated administration of brofaromine (BRO) and moclobemide (MOC)--monoamine oxidase A (MAO-A) inhibitors as well as deprenyl (DEP)--monoamine oxidase B (MAO-B) inhibitor on behavior of rats in acoustic startle response test were studied. For comparison the tricyclic antidepressant amitriptyline (AMI) was also studied. BRO given in a single dose of 10 mg/kg diminished the amplitude of acoustic startle response, while in a dose of 30 mg/kg had no effect. MOC diminished the amplitude when given in a single dose of 30 mg/kg, and had no effect in a dose of 10 mg/kg. Both MAO type A inhibitors diminished the startle reaction amplitude when tested 2 h after the last dose of a repeated treatment (twice daily for 14 days, 10 or 30 mg/kg, po). 5 days after the last dose the treatments did not affect the response. DEP given both in a single dose of 0.25 mg/kg and repeatedly for 15 and 21 days, increased the amplitude of startle reaction immediately after completion of the treatment. 9 days after drug withdrawal this effect was not observed. DEP in a dose of 1.0 mg/kg had no effect on the amplitude of startle reaction in any experiments described above. The above results demonstrate that MAO-A inhibitors--brofaromine and moclobemide and a MAO-B inhibitor--deprenyl show opposit activity in acoustic startle response test. BRO and MOC exert the inhibitory activity, whereas DEP has an excitatory effect on the startle reaction. The reference drug, AMI had no effect when given in a single doses (2 and 10 mg/kg, po). After repeated treatment (twice daily for 14 days, 2 or 10 mg/kg, po), AMI diminished the amplitude of the startle reaction only in higher dose when tested 2 h after the last dose and had no effect in the experiment carried out 5 days after the last dose.
本文研究了单胺氧化酶A（MAO - A）抑制剂溴法罗明（BRO）和吗氯贝胺（MOC）以及单胺氧化酶B（MAO - B）抑制剂司来吉兰（DEP）单次及重复给药对大鼠听觉惊吓反应试验行为的影响。为作比较，还研究了三环类抗抑郁药阿米替林（AMI）。单次给予10mg/kg的BRO可降低听觉惊吓反应的幅度，而30mg/kg剂量则无作用。单次给予30mg/kg的MOC可降低幅度，10mg/kg剂量则无作用。两种MAO - A抑制剂在重复治疗（每日两次，共14天，10或30mg/kg，口服）最后一剂后2小时测试时均降低了惊吓反应幅度。最后一剂后5天进行的试验中，这些治疗均未影响反应。单次给予0.25mg/kg以及重复给药15天和21天的DEP，在治疗结束后立即增加了惊吓反应幅度。停药9天后未观察到该效应。1.0mg/kg剂量的DEP在上述任何实验中对惊吓反应幅度均无作用。上述结果表明，MAO - A抑制剂——溴法罗明和吗氯贝胺以及MAO - B抑制剂——司来吉兰在听觉惊吓反应试验中表现出相反的活性。BRO和MOC发挥抑制活性，而DEP对惊吓反应有兴奋作用。参比药物AMI单次给药（2和10mg/kg，口服）时无作用。重复治疗（每日两次，共14天，2或10mg/kg，口服）后，AMI仅在最后一剂后2小时测试时较高剂量下降低了惊吓反应幅度，在最后一剂后5天进行的实验中无作用。
