Hashimoto K, Oguro K, Furuta Y
Arch Histol Jpn. 1977;40 Suppl:129-32. doi: 10.1679/aohc1950.40.supplement_129.
The effects of dopamine and L-dopa on the exocrine secretion of the pancreas were compared in rats, cats, rabbits and dogs. Dopamine and its precursor, L-dopa, induced a secretin-like stimulation in dogs, while their effects were significantly less in rats. The dopaminergic receptor stimulus was involved in the exocrine secretion of the pancreas in dogs, whereas in rats, the beta-adrenergic receptor was involved. Spontaneous secretion in the resting state was present in rabbits but absent in cats. This spontaneous secretion in rabbits could be definitely inhibited by either dopamine or L-dopa. The secretin-induced secretion in both rabbits and cats was markedly inhibited by either dopamine or L-dopa. Species difference in the secretory response to dopamine in the pancreas of dogs, cats, rabbits and rats may be ascribed to the difference in the incorporation of exogenous L-dopa and dopamine in the exocrine cells of the pancreas.
在大鼠、猫、兔和狗身上比较了多巴胺和左旋多巴对胰腺外分泌的影响。多巴胺及其前体左旋多巴在狗身上可诱导出类似促胰液素的刺激作用，而在大鼠身上其作用则明显较弱。多巴胺能受体刺激参与了狗胰腺的外分泌，而在大鼠身上，β - 肾上腺素能受体参与其中。静息状态下的自发分泌在兔身上存在，但在猫身上不存在。兔身上的这种自发分泌可被多巴胺或左旋多巴明确抑制。多巴胺或左旋多巴均可显著抑制兔和猫体内促胰液素诱导的分泌。狗、猫、兔和大鼠胰腺对多巴胺分泌反应的种属差异可能归因于胰腺外分泌细胞中外源性左旋多巴和多巴胺摄取的差异。
