维拉帕米对犬体内多巴胺、促胰液素和胰酶泌素诱导的胰腺外分泌的影响。

Effects of verapamil on pancreatic exocrine secretion induced by dopamine, secretin and pancreozymin in the dog.

Iwatsuki K, Ikeda K, Chiba S

Clin Exp Pharmacol Physiol. 1982 Mar-Apr;9(2):165-72. doi: 10.1111/j.1440-1681.1982.tb00793.x.

Abstract

The effects of verapamil on dopamine-, secretin- and pancreozymin-induced pancreatic secretion were investigated in the isolated, blood-perfused canine pancreas in vivo. 2. The volume of pancreatic secretion either in the resting state or induced by pancreozymin given intra-arterially (i.a.) was decreased by an infusion of 5 micrograms/min of verapamil; that induced by dopamine or secretin i.a. was also decreased but the changes were not statistically significant. 3. Protein concentration in pancreatic juice either in the resting state or in that of stimulated secretion by pancreozymin was decreased significantly, but protein concentration induced by dopamine or secretin was not affected, by verapamil treatment. 4. Verapamil had no effect on bicarbonate concentration in pancreatic juice secreted either in the resting state or when stimulated by these secretagogues.5. These results suggest that verapamil, at least in part, may affect the secretory mechanisms of acinar cells but not that of the ductular cells.

摘要

在体外用血液灌注的离体犬胰腺中，研究了维拉帕米对多巴胺、促胰液素和胰酶泌素诱导的胰腺分泌的影响。2. 以5微克/分钟的速度输注维拉帕米，可使处于静息状态或经动脉内（i.a.）给予胰酶泌素诱导的胰腺分泌量减少；经动脉内给予多巴胺或促胰液素诱导的分泌量也减少，但变化无统计学意义。3. 维拉帕米处理可使静息状态下或胰酶泌素刺激分泌状态下胰液中的蛋白质浓度显著降低，但对多巴胺或促胰液素诱导的蛋白质浓度无影响。4. 维拉帕米对静息状态下或受这些促分泌素刺激时分泌胰液中的碳酸氢盐浓度均无影响。5. 这些结果表明，维拉帕米至少部分地可能影响腺泡细胞的分泌机制，但不影响导管细胞的分泌机制。