Medizinische Biochemie und Molekularbiologie, Universität des Saarlandes, Gebäude 44, 66424, Homburg, Germany.
Cell Tissue Res. 2010 Nov;342(2):139-46. doi: 10.1007/s00441-010-1068-3. Epub 2010 Oct 27.
Protein phosphorylation is a key regulatory post-translational modification and is involved in the control of many cellular processes. Protein kinase CK2, formerly known as casein kinase II, which is a ubiquitous and highly conserved protein serine/threonine kinase, plays a central role in the control of a variety of pathways in cell proliferation, transformation, apoptosis and senescence. An understanding of the regulation of such a central protein kinase would greatly help our comprehension of the regulation of many pathways in cellular regulation. A number of reviews have addressed the detection, the development, and the characterization of inhibitors of CK2. The present review focuses on possible natural regulators of CK2, i.e. proteins and other cellular factors that bind to CK2 and thereby regulate its activity.
蛋白质磷酸化是一种关键的调节性翻译后修饰，参与控制许多细胞过程。蛋白激酶 CK2，以前称为酪蛋白激酶 II，是一种普遍存在且高度保守的蛋白丝氨酸/苏氨酸激酶，在控制细胞增殖、转化、凋亡和衰老等多种途径中起着核心作用。对这种中心蛋白激酶的调节的理解将极大地帮助我们理解细胞调节中许多途径的调节。许多综述已经探讨了 CK2 的检测、开发和抑制剂的特性。本综述重点介绍 CK2 的可能天然调节剂，即与 CK2 结合并调节其活性的蛋白质和其他细胞因子。
