搏动性偏头痛疼痛与动脉脉搏之间的时间关系。
On the temporal relationship between throbbing migraine pain and arterial pulse.
机构信息
Department of Neurology, McKnight Brain Institute, University of Florida, 100 South Newell Dr., Gainesville, FL 32610, USA.
出版信息
Headache. 2010 Oct;50(9):1507-10. doi: 10.1111/j.1526-4610.2010.01765.x.
OBJECTIVE AND BACKGROUND
The characteristic throbbing quality of migraine pain is often attributed to the periodic activation of trigeminovascular sensory afferents triggered by the distension of cranial arteries during systole, but direct evidence for this model has been elusive.
DESIGN AND METHODS
Patients with throbbing migrainous pain were asked to signal in real time the occurrences of their subjective experience of pulsating pain, during which time their arterial pulse was independently monitored.
RESULTS
Overall, the throbbing pain rate (61.7 ± 5.5 SEM) was substantially slower than the arterial pulse rate (80 ± 2.6 SEM, P < .02), and among the few individuals in whom the 2 rates were the same or nearly the same, the occurrences of throbbing and arterial pulsations fell in and out of phase with each other.
CONCLUSIONS
The lack of a simple correspondence between the subjective experience of throbbing pain and the arterial pulse would at the very least require extensive refinement of the prevailing view that the subjective experience of throbbing migraine pain is directly related to the distension of cranial arteries and activation of associated sensory afferents.
目的和背景
偏头痛疼痛的特征性搏动性质通常归因于在收缩期期间颅动脉扩张触发的三叉血管感觉传入的周期性激活，但该模型的直接证据一直难以捉摸。
设计和方法
要求搏动性偏头痛疼痛的患者实时发出他们主观的搏动性疼痛体验的发生信号，同时独立监测他们的动脉脉搏。
结果
总体而言，搏动性疼痛的频率（61.7 ± 5.5 SEM）明显慢于动脉脉搏的频率（80 ± 2.6 SEM，P <.02），并且在少数搏动性疼痛频率和动脉搏动频率相同或几乎相同的个体中，搏动和动脉搏动的发生彼此之间相互失步。
结论
搏动性疼痛的主观体验与动脉脉搏之间缺乏简单的对应关系，至少需要对普遍观点进行广泛的修正，即搏动性偏头痛疼痛的主观体验与颅动脉扩张和相关感觉传入的激活直接相关。
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