[2007年至2009年分离的奇异变形杆菌菌株中广谱β-内酰胺酶的发生率]
[The incidence of extended spectrum beta-lactamases in Proteus mirabilis strains isolated in 2007-2009].
作者信息
Kwiecińska-Piróg Joanna, Bogiel Tomasz, Gospodarek Eugenia
机构信息
Katedra i Zakład Mikrobiologii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu.
出版信息
Przegl Epidemiol. 2010;64(3):395-8.
Proteus sp. rods are opportunistic human pathogens, isolated mainly from urinary tract infections. They are naturally susceptible to most antimicrobials. However, acquisition of genes for extended spectrum beta-lactamases on plasmids and irrational antimicrobial treatment increase amount of multidrug resistant strains and lead to their selection. The aim of this study was to evaluate production of ESBLs by double disc synergy test and antimicrobial susceptibility of P mirabilis strains by disc diffusion method. Strains included into the study were isolated from patients of dr A. Jurasz University Hospital No 1 in Bydgoszcz between 2007 and 2009. P mirabilis strains were isolated mainly from urine. In this study 10,4%, 18,7% and 14,4% ESBL(+) P mirabilis strains were isolated in 2007, 2008, 2009, respectively. Resistance to majority of the investigated antimicrobials was observed in ESBL(+) P mirabilis strains.
变形杆菌属杆菌是机会性人类病原体，主要从尿路感染中分离得到。它们对大多数抗菌药物天然敏感。然而，质粒上获得超广谱β-内酰胺酶基因以及不合理的抗菌治疗增加了多重耐药菌株的数量并导致其被选择出来。本研究的目的是通过双纸片协同试验评估奇异变形杆菌菌株产生超广谱β-内酰胺酶的情况，并通过纸片扩散法评估其对抗菌药物的敏感性。纳入本研究的菌株是2007年至2009年期间从比得哥什第一A. 尤拉什大学医院的患者中分离得到的。奇异变形杆菌菌株主要从尿液中分离得到。在本研究中，2007年、2008年和2009年分别分离出10.4%、18.7%和14.4%的产超广谱β-内酰胺酶（ESBL(+)）奇异变形杆菌菌株。在产超广谱β-内酰胺酶（ESBL(+)）奇异变形杆菌菌株中观察到对大多数所研究抗菌药物的耐药性。
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