Saito R, Okugawa S, Kumita W, Sato K, Chida T, Okamura N, Moriya K, Koike K
Department of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan.
Clin Microbiol Infect. 2007 Dec;13(12):1204-6. doi: 10.1111/j.1469-0691.2007.01826.x. Epub 2007 Sep 11.
This study investigated the clinical characteristics of ciprofloxacin-resistant Proteus mirabilis isolates from urine samples associated with nosocomial infection or colonisation, and identified the risk-factors for ciprofloxacin resistance. Data for patients with ciprofloxacin-resistant P. mirabilis isolates (n=13) were compared with those for randomly selected patients with ciprofloxacin-susceptible P. mirabilis isolates (n=40) who were matched by temporal occurrence as control patients. The majority of ciprofloxacin-resistant P. mirabilis isolates were multiresistant, and ciprofloxacin resistance was associated significantly with previous use of fluoroquinolones and production of extended-spectrum beta-lactamases.
本研究调查了与医院感染或定植相关的尿液样本中耐环丙沙星奇异变形杆菌分离株的临床特征，并确定了环丙沙星耐药的危险因素。将耐环丙沙星奇异变形杆菌分离株患者（n = 13）的数据与随机选择的、按时间匹配作为对照患者的环丙沙星敏感奇异变形杆菌分离株患者（n = 40）的数据进行比较。大多数耐环丙沙星奇异变形杆菌分离株具有多重耐药性，环丙沙星耐药与先前使用氟喹诺酮类药物以及产超广谱β-内酰胺酶显著相关。
