Department of Pathology, School of Medicine, University of Washington, Seattle 98104, USA.
J Infect Dis. 2010 Dec 1;202(11):1667-70. doi: 10.1086/657083. Epub 2010 Oct 26.
Prospective studies of the persistence of human papillomavirus (HPV) variants are rare and typically small. We sequenced HPV-16 variants in longitudinal pairs of specimens from 86 women enrolled in the ASCUS-LSIL Triage Study. A change of variants was identified in 4 women (4.7% [95% confidence interval, 1.3%-11.5%]). Among women with intervening HPV results (n = 60), a variant switch occurred in 2 of 11 who had evidence of intervening negativity for HPV-16, compared with 1 of 49 who consistently tested positive (P = .11). These results suggest the possibility that rare misclassification of transient infections as persistent infections occurs in natural history studies of type-specific HPV infections.
前瞻性研究 HPV 变体的持续性非常罕见，且通常规模较小。我们对 86 名参加 ASCUS-LSIL 分流研究的女性的纵向标本进行 HPV-16 变体测序。在 4 名女性（4.7%[95%置信区间，1.3%-11.5%]）中发现了变体变化。在 HPV 结果有间隔的女性中（n=60），在 11 名 HPV-16 间歇性阴性的女性中有 2 名出现变体转换，而在持续阳性的 49 名女性中有 1 名（P=.11）。这些结果表明，在 HPV 型别特异性感染的自然史研究中，一过性感染被罕见地错误分类为持续性感染的可能性。
