School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.
Med Chem. 2010 Sep;6(5):286-97. doi: 10.2174/157340610793358864.
Thioredoxin reductase plays a critical role in the regulation of cancer cell apoptosis, making it an attractive target for the design of new anticancer drugs. Several classes of compounds have been considered as potential antitumor or chemopreventive agents; most of them apparently interact with thioredoxin reductase's C-terminal redox center.
硫氧还蛋白还原酶在调控癌细胞凋亡中起着至关重要的作用，使其成为设计新型抗癌药物的有吸引力的靶点。几类化合物被认为是有潜力的抗肿瘤或化学预防药物；其中大多数显然与硫氧还蛋白还原酶的 C 端氧化还原中心相互作用。
