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[局部麻醉药中毒的解毒剂:脂质乳剂静脉给药的新用途]

[Antidote against local anaesthetic intoxication: new use of lipid emulsion for intravenous administration].

作者信息

ter Horst Maarten, Tjiang Gilbert C H, Luitwieler Ronald L, van Velzen Chris, Stolker Robert Jan, de Quelerij Marcel

机构信息

Erasmus MC, afd. Anesthesiologie, Rotterdam, the Netherlands.

出版信息

Ned Tijdschr Geneeskd. 2010;154:A1302.

Abstract

Local anaesthetics are routinely used for several indications, but despite local administration their use may lead to systemic toxicity. The symptoms include numbness of the tongue, dizziness, tinnitus, visual disturbances, muscle spasms, convulsions, coma, and respiratory and cardiac arrest. Recently, an intravenous lipid emulsion was reported to act as a novel potential antidote for systemic toxicity due to local anaesthetics. We describe the application of this lipid emulsion in a 27-year-old patient with generalized seizures and coma due to local anaesthetic toxicity. She recovered quickly and was responsive again 10 minutes after the intravenous administration of the lipid emulsion.

摘要

局部麻醉药常用于多种适应症,但尽管是局部给药,其使用仍可能导致全身毒性。症状包括舌头麻木、头晕、耳鸣、视觉障碍、肌肉痉挛、抽搐、昏迷以及呼吸和心脏骤停。最近,有报道称静脉注射脂质乳剂可作为一种新型的潜在解毒剂,用于治疗局部麻醉药引起的全身毒性。我们描述了这种脂质乳剂在一名27岁因局部麻醉药中毒而出现全身性癫痫发作和昏迷的患者中的应用。她恢复迅速,在静脉注射脂质乳剂10分钟后再次恢复意识。

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